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- Models of Investigation
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41 min
1. Antifungal innate immunity in C. elegans- Dr. Jonathan Ewbank
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44 min
2. The anti-microbial defense of Drosophila: a paradigm for innate immunity- Prof. Jules Hoffmann
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38 min
3. Phagocytosis in the fruit fly, Drosophila melanogaster- Dr. Lynda Stuart
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62 min
4. Innate immune sensing and response- Prof. Bruce Beutler
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61 min
5. Macrophages and systems biology- Prof. David Hume
- Cell Types and Recruitment
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71 min
6. Leukocyte recruitment in vivo- Prof. Paul Kubes
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51 min
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42 min
8. Eosinophils- Prof. Tim Williams
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63 min
9. Dendritic cells: linking innate to different forms of adaptive immunity- Prof. Ralph Steinman
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25 min
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61 min
11. Innate-like lymphocytes 1- Prof. Adrian Hayday
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41 min
12. Innate-like lymphocytes 2- Prof. Adrian Hayday
- Recognition and Signaling
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50 min
13. Colony stimulating factor-1 regulation of macrophages in development and disease- Prof. E. Richard Stanley
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42 min
14. Fc receptors: linking innate and acquired immunity- Prof. Ken G C Smith
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39 min
15. Phagocytosis- Prof. Joel Swanson
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44 min
16. Clearance of apoptotic cells and the control of inflammation- Prof. Sir John Savill
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38 min
17. Signaling by innate immune receptors- Prof. Michael Karin
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41 min
18. Nuclear receptors at the crossroads of inflammation and atherosclerosis- Prof. Christopher Glass
- Modulation of Effector Responses
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22 min
19. Humoral innate immunity and the acute phase response 1- Prof. Alberto Mantovani
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42 min
20. Humoral innate immunity and the acute phase response 2- Prof. Alberto Mantovani
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54 min
21. Cytokines regulating the innate response- Prof. Anne O’Garra
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39 min
22. Arginase and nitric oxide- Dr. Peter Murray
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38 min
23. Novel lipid mediators in resolution of inflammation- Prof. Charles Serhan
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69 min
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42 min
25. Cationic peptides in innate immunity- Dr. Dawn Bowdish
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27 min
26. Iron metabolism and innate immunity- Prof. Tomas Ganz
- Pathogen-Host Interactions
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46 min
27. Innate recognition of viruses- Prof. Caetano Reis e Sousa
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50 min
28. Type I interferons in innate immunity to viral infections- Prof. Christine Biron
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56 min
29. HIV-1 and immunopathogenesis: innate immunity- Prof. Luis Montaner
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53 min
30. Understanding and combating tuberculosis- Prof. David Russell
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34 min
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51 min
32. Innate immunity and malaria- Prof. Douglas Golenbock
- Health and Disease
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39 min
33. Innate immunity in children- Prof. David Speert
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59 min
34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis- Prof. Sir Ravinder Maini
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33 min
35. NOD-like receptors in innate immunity and inflammatory disease- Prof. Gabriel Nunez
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38 min
36. Paneth cells in innate immunity and inflammatory bowel disease- Prof. Satish Keshav
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36 min
37. Innate immunity in the brain in health and disease- Prof. V. Hugh Perry
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54 min
38. The fate of monocytes in atherosclerosis- Prof. Gwendolyn Randolph
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49 min
39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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73 min
40. Monocyte/macrophages in innate immunity- Prof. Emeritus Siamon Gordon
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32 min
41. Innate immunity in C. elegans- Dr. Jonathan Ewbank
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51 min
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39 min
43. NLR genes: infection, inflammation and vaccines- Prof. Jenny Ting
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63 min
44. Manipulation of innate immune response: lessons from shigella- Prof. Philippe Sansonetti
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35 min
45. Innate immunity of the lung and adaptation to air breathing at birth- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- Atherosclerosis
- Areas of atherosclerotic plaques development
- Accumulation of "dendritic cells" in the artery
- TLR2 expression in endothelial cells
- Early stage of the disease
- Heterogeneity of macrophages in the plaques
- DCs in human atherosclerotic plaques
- Importance of monocytes in atherosclerosis
- Hematopoietic cells involved in atherosclerosis
- Human monocyte subsets
- Differences between human monocyte subsets
- Human vs. mouse monocyte subsets
- A method for monitoring monocyte migration
- Monocyte recruitment to plaques
- Mouse monocyte recruitment to inflammatory sites
- Inflammatory monocytes
- Ly-6Clo monocytes role in plaques
- Mannose receptor positive monocytes in plaques
- Is the CX3CR1 allele athero-protective?
- CX3CR1 as a survival factor
- Progression of atherosclerosis
- Features of advanced disease
- Dramatic view of a necrotic core
- Resolution of acute inflammation
- Does this resolution occur in atherosclerosis?
- Schematic diagram of atherosclerotic plaque
- Leukocyte trafficking
- Cells emigrate from lesions
- CD68+ cell in the SMC medial layer of the artery
- Migration of mononuclear phagocytes - method 1
- DC-like cells fail to leave progressing plaques
- Quantification of the surgical process
- The effect of the surgical process
- Migration of mononuclear phagocytes - method 2
- Distinguishing death from trafficking
- A schematic view of the monitoring process
- Pulse-chase experiment
- Late-time point of monitoring
- Potential therapeutic targets
- How is mobilization achieved?
- Thank you
Topics Covered
- Initiation of atherosclerosis and importance of monocytes
- Description of monocyte subsets
- Tracking of monocyte subsets into plaques
- Macrophage subtypes and possible relevance to atherosclerosis
- CX3CR1 in atherosclerosis |Resolution of inflammation and its failure in atherosclerosis
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Randolph, G. (2009, June 30). The fate of monocytes in atherosclerosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/AVUS3976.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Gwendolyn Randolph has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The fate of monocytes in atherosclerosis
Published on June 30, 2009
54 min
