Integral gene drives for malaria control
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- Fundamentals of Evolution and Medicine
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50 min
1. Evolutionary medicine- Prof. Randolph Nesse
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38 min
2. Evolution and medicine: from the perspective of an evolutionary biologist- Prof. Stephen C. Stearns
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31 min
3. Developmental plasticity, evolution and the origins of disease- Dr. Mary Jane West-Eberhard
- Evolutionary Genetics
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47 min
4. Genetic variation and human disease- Dr. David Houle
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46 min
5. Ecogenetics, evolutionary biology and human disease- Prof. Gilbert Omenn
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24 min
6. Race in genetics and medicine- Prof. Jeffrey Long
- Infectious Disease
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44 min
-
39 min
8. Evolutionary arms races- Prof. Mark Pagel
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36 min
9. Evolution of drug resistance- Dr. Pleuni Pennings
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34 min
10. Evolution of virulence: malaria, a case study- Prof. Andrew Read
- Defenses
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36 min
11. Fever and related defenses- Prof. Matthew Kluger
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45 min
12. The evolutionary ecology of immunity- Prof. Paul Schmid-Hempel
- Novel Environmental Factors
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39 min
13. What did humans evolve to eat? evolutionary perspectives on human nutritional health- Prof. William R. Leonard
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45 min
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49 min
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31 min
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31 min
17. Diseases of civilization: an evolutionary legacy- Prof. Alan Weder
- Problems Arising From Constraints and Trade-Offs
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51 min
18. Aging and evolutionary medicine- Prof. Linda Partridge
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45 min
19. Human aging and menopause- Prof. Kristen Hawkes
- Sex and Reproduction
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32 min
20. Setting the second stage: the evolution of menopause & post-reproductive life- Prof. Lynnette Sievert
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44 min
21. Evolutionary obstetrics- Prof. Wenda Trevathan
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41 min
22. Sex differences in mortality- Dr. Daniel Kruger
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46 min
23. The endocrinology of human life history transitions- Prof. Peter Ellison
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43 min
24. Genetic conflicts in human pregnancy- Prof. David Haig
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57 min
25. Environmental effects on human reproduction- Prof. Gillian Bentley
- Cancer
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54 min
26. A darwinian eye view of cancer- Prof. Mel Greaves
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56 min
27. Viruses and cancer- Prof. Robin Weiss
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38 min
28. Connecting aging and cancer through the lens of evolution- Prof. James DeGregori
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44 min
29. Evolutionary dynamics in cancer control and cure- Dr. Bob Gatenby
- Specific Body Systems
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44 min
30. Hard tissue biology in human health and evolution: enamel biology- Prof. Timothy Bromage
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19 min
31. Hard tissue biology in human health and evolution: bone biology- Prof. Timothy Bromage
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46 min
32. Hard tissue biology in human health and evolution: craniofacial biology- Prof. Timothy Bromage
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26 min
33. Hard tissue biology in human health and evolution: life history and chronobiology- Prof. Timothy Bromage
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53 min
34. Lung biology and lung disease- Prof. John S. Torday
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30 min
35. The evolutionary web of life- Prof. John S. Torday
- Mental Disorders
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38 min
36. Evolutionary psychiatry- Prof. Randolph Nesse
- Paediatrics
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41 min
37. Evolutionary pediatrics- Dr. Paul Turke
- Microbiome
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49 min
38. Evolution, the microbiome, and human health- Dr. Joe Alcock
- Archived Lectures *These may not cover the latest advances in the field
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42 min
39. The hygiene hypothesis- Prof. Graham Rook
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26 min
40. Mapping motivations: evolutionary health promotion- Dr. Valerie Curtis
- Dr. Robert Aunger
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16 min
41. Evolutionary biology of depression- Prof. Lewis Wolpert
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52 min
42. Evolutionary genetic epidemiology- Prof. Nicholas Schork
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65 min
43. Mental disorders in the light of evolutionary biology- Prof. Randolph Nesse
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59 min
44. Evolution: medicine's missing basic science- Prof. Randolph Nesse
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47 min
45. Environmental effects on human reproduction- Prof. Gillian Bentley
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65 min
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46 min
47. Health disparities in common complex diseases: a role for genetics?- Dr. Kathleen Barnes
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38 min
48. Infection and chronic disease- Prof. Paul Ewald
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42 min
49. The paleolithic lifestyle and prevention of chronic disease- Prof. S. Boyd Eaton
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32 min
50. Evolutionary considerations and the endothelium- Dr. William Aird
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48 min
51. Evolutionary behavioural genetics and mental disorders- Dr. Matthew Keller
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57 min
52. Audience questions about evolution and medicine- Prof. Randolph Nesse
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32 min
53. Why we cook with spices: preventative darwinian medicine- Prof. Paul Sherman
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43 min
54. Antibiotic resistance and hospital-acquired infection- Dr. Carl Bergstrom
Printable Handouts
Navigable Slide Index
- Introduction
- What is 'evolutionary genetic epidemiology'?
- Goals of evolutionary genetic epidemiology
- Evolutionary-mediated human disease phenotypes
- Genetic dissection of complex traits
- How are genetic association studies pursued? (1)
- How are genetic association studies pursued? (2)
- Whole genome association (WGA) studies
- Recent large-scale WGA initiatives in the US
- Combining evolution with association studies
- Polymorphism: the 'wheat' and the 'chaffe'
- Population stratification and false positive results
- Genetic heterogeneity and false negative results
- Evolutionary conservation and putative functionality
- Genetic variation in CHGA gene
- DNA sequence vs. structural conservation
- Human genetic background heterogeneity
- Genotypic/phenotypic differentiation maintenance
- Shifting balance of evolution theory
- Classical 'supervised' studies
- Contemporary 'unsupervised' studies
- Use of tree diagrams to represent genetic diversity
- Diseases differ in frequency across populations
- Lactase phenotype and population differentiation
- ASPM gene and population differentiation
- Overcoming stratification/heterogeneity problem
- Sorting out genetic backgrounds of individuals
- Race, genetic background, and drug prescriptions
- Race and analysis of genetic variation
- Ancestry informative markers (AIMs)
- Example admixture studies using AIMs
- Global map of skin pigmentation levels
- Melanin content and individual ancestry
- The "evolution" of human communities
- Genetic demography variation in local community
- Community metagenomic analysis
- Conclusions
- The Schork laboratory: 2006-2008
Topics Covered
- What is 'evolutionary genetics'?
- Evolution, genetic variation and association analyses
- Withinspecies diversity and population genetics
- Human genetic diversity and phenotypic variation
- Human community 'metagenomics'
Talk Citation
Schork, N. (2007, October 1). Evolutionary genetic epidemiology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved July 1, 2025, from https://doi.org/10.69645/KQZV9689.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Nicholas Schork has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
