Registration for a live webinar on 'Innate immunity, inflammation and cancer' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Co-ordination of G1 Progression
-
1. START control in yeast
- Prof. Curt Wittenberg
-
2. The pRB/E2F pathway
- Prof. Jacqueline Lees
-
3. Cell cycle control by the ubiquitin system in mammals
- Prof. Michele Pagano
- Chromosome Duplication
-
4. Replication licensing
- Prof. Julian Blow
-
5. Initiation of DNA replication
- Prof. Bruce Stillman
-
6. Regulation of replication fork progression and stability
- Dr. Luis Aragón
-
7. Nucleosome assembly during DNA replication
- Dr. Alain Verreault
- Preparing for Mitosis
-
8. Sister chromatid cohesion: simple concept, complex reality
- Prof. Douglas Koshland
-
9. Mitotic chromosome condensation
- Prof. Andrew Belmont
-
10. Centrosome duplication and separation in animal cells
- Prof. Andrew Fry
- Spindle Assembly and Chromosome Segregation
-
11. Bipolar spindle assembly
- Dr. Eric Karsenti
-
12. Chromosome bi-orientation in yeast
- Prof. Mike Stark
- Prof. Tomo Tanaka
- Mitotic Exit and Cytokinesis
-
14. Cleavage furrow formation and ingression during animal cytokinesis
- Dr. Pier Paolo D'Avino
- Checkpoints Governing Cell Cycle Progression
-
15. The DNA damage response
- Dr. Vincenzo Costanzo
-
16. The spindle checkpoint
- Dr. Kevin Hardwick
-
17. Spindle movement and checkpoint control during mitosis in yeast
- Prof. John Cooper
-
18. The G2/M transition
- Prof. Dr. René Medema
- The Cell Cycle in Development and Cancer
-
19. Mouse models to investigate cell cycle and cancer
- Dr. Philipp Kaldis
-
20. Cell cycle: a complex network of signals regulating cell proliferation
- Prof. Antonio Giordano
-
21. Drug discovery and target validation in the p53 pathway
- Prof. Sir David Lane
-
22. Role and regulation of Cdk inhibitors in development and cancer
- Prof. Martine Roussel
-
24. The Myc transcription factor network
- Prof. Robert N. Eisenman
- Meiosis: A Specialized Cell Cycle
-
25. Recombination and the formation of chiasmata in meiosis
- Prof. Matthew Whitby
- Archived Lectures *These may not cover the latest advances in the field
-
26. Geometric regulation of kinetochore orientation
- Prof. Yoshinori Watanabe
Printable Handouts
Navigable Slide Index
- Introduction
- Cytokinesis is the final act of cell division
- Different populations of microtubules in cytokinesis
- Co-ordination of events during cytokinesis
- RhoA effect on actomyosin ring
- Inactivation of RhoA causes cytokinesis failure
- RhoA activation is a key event for actomyosin ring
- What determines the cleavage plane position?
- Astral relaxation
- Disassembly of aster microtubules
- Astral microtubules inhibit RhoA activation
- Equatorial and central spindle stimulation
- Microtubules are necessary for RhoA activation
- Microtubules contact the future cleavage site (1)
- Microtubules contact the future cleavage site (2)
- Dual role for microtubules in RhoA activation
- Molecular nature of furrow inducing signal
- RacGAP component of centralspindlin
- Both pav and RacGAP are necessary for furrowing
- Localization of centralspindlin prior to furrowing
- Regulation of the centralspindlin accumulation
- Cdk1 inhibits MKLP-1-microtubules interaction
- RacGAP promotes RhoA activation
- Cleavage furrow formation and ingression (1)
- Properties of the RacGAP component
- Cleavage furrow formation and ingression (2)
- CD8:RacGAP promotes ectopic furrowing
- CD8::RacGAP50C induces ectopic furrows
- Ectopic furrows induced by CD8::RacGAP
- How can CD8:RacGAP recruit anillin?
- Anillin, a scaffold protein
- Anillin localization during the cell cycle
- Anillin equatorial recruitment
- Proteins interacting with anillin
- RacGAP50C co-localizes with anillin
- Anillin binds RacGAP50C through its C terminus
- RacGAP50C binds anillin and pav in different sites
- Anillin-summary
- Membrane formation during cytokinesis
- Sources of new membrane at the cleavage site
- Internal membrane reservoirs
- Molecules involved in membrane trafficking
- Membrane trafficking during cytokinesis
- RacGAP interacts with FIP3
- RacGAP is a key regulator in cytokinesis
- Acknowledgments
- Appendix: references
Topics Covered
- Co-ordination of multiple events during cytokinesis
- Assembly and contraction of the actomyosin ring: the role of RhoA
- Cleavage plane determination
- The role of microtubules in positioning the cleavage plane
- The molecular nature of the furrow inducing signal
- The centralspindlin complex
- The role of Anillin during cytokinesis
- Interaction between Anillin and centralspindlin connects the contractile ring with spindle microtubules
- Membrane formation during cytokinesis
- The origin of new membrane for the cleavage site
- Molecules involved in membrane trafficking during cytokinesis
- The multiple roles of the RacGAP component of the centralspindlin complex during cytokinesis
Talk Citation
D'Avino, P.P. (2009, April 30). Cleavage furrow formation and ingression during animal cytokinesis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/1264/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Pier Paolo D'Avino has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.