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1. Introduction
2. Cytokinesis is the final act of cell division
3. Different populations of microtubules in cytokinesis
4. Co-ordination of events during cytokinesis
5. RhoA effect on actomyosin ring
6. Inactivation of RhoA causes cytokinesis failure
7. RhoA activation is a key event for actomyosin ring
8. What determines the cleavage plane position?
9. Astral relaxation
10. Disassembly of aster microtubules
11. Astral microtubules inhibit RhoA activation
12. Equatorial and central spindle stimulation
13. Microtubules are necessary for RhoA activation
14. Microtubules contact the future cleavage site (1)
15. Microtubules contact the future cleavage site (2)
16. Dual role for microtubules in RhoA activation
17. Molecular nature of furrow inducing signal
18. RacGAP component of centralspindlin
19. Both pav and RacGAP are necessary for furrowing
20. Localization of centralspindlin prior to furrowing
21. Regulation of the centralspindlin accumulation
22. Cdk1 inhibits MKLP-1-microtubules interaction
23. RacGAP promotes RhoA activation
24. Cleavage furrow formation and ingression (1)
25. Properties of the RacGAP component
26. Cleavage furrow formation and ingression (2)
27. CD8:RacGAP promotes ectopic furrowing
28. CD8::RacGAP50C induces ectopic furrows
29. Ectopic furrows induced by CD8::RacGAP
30. How can CD8:RacGAP recruit anillin?
31. Anillin, a scaffold protein
32. Anillin localization during the cell cycle
33. Anillin equatorial recruitment
34. Proteins interacting with anillin
35. RacGAP50C co-localizes with anillin
36. Anillin binds RacGAP50C through its C terminus
37. RacGAP50C binds anillin and pav in different sites
38. Anillin-summary
39. Membrane formation during cytokinesis
40. Sources of new membrane at the cleavage site
41. Internal membrane reservoirs
42. Molecules involved in membrane trafficking
43. Membrane trafficking during cytokinesis
44. RacGAP interacts with FIP3
45. RacGAP is a key regulator in cytokinesis
46. Acknowledgments
47. Appendix: references

Topics Covered

• Co-ordination of multiple events during cytokinesis
• Assembly and contraction of the actomyosin ring: the role of RhoA
• Cleavage plane determination
• The role of microtubules in positioning the cleavage plane
• The molecular nature of the furrow inducing signal
• The centralspindlin complex
• The role of Anillin during cytokinesis
• Interaction between Anillin and centralspindlin connects the contractile ring with spindle microtubules
• Membrane formation during cytokinesis
• The origin of new membrane for the cleavage site
• Molecules involved in membrane trafficking during cytokinesis
• The multiple roles of the RacGAP component of the centralspindlin complex during cytokinesis

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Talk Citation

D'Avino, P.P. (2009, April 30). Cleavage furrow formation and ingression during animal cytokinesis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/OTQI4202.
Export Citation (RIS)

Publication History

• Published on April 30, 2009

Financial Disclosures

• Dr. Pier Paolo D'Avino has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.