• Epidemiology
• 37 min
  1. Assessment of obesity and classification of patients: historical perspectives and current practice

  • Prof. George Bray
• 40 min
  2. Epidemiology of obesity

  • Prof. Jacob Seidell
• Etiology and Causes
• 59 min
  3. Metabolic, adipose tissue and muscle predictors of obesity

  • Prof. Ian Macdonald
• 41 min
  4. Neural control of food intake and energy balance

  • Prof. Hans-Rudolf Berthoud
• 64 min
  5. Understanding obesity: genes and environment in the determination of body weight

  • Prof. Rudy Leibel
• 47 min
  6. Dietary determinants of obesity

  • Prof. Arne Astrup
• 42 min
  7. Physical inactivity as a determinant of obesity

  • Prof. Wim Saris
• 42 min
  8. Environmental causes of obesity: sociocultural, built environment and economic factors

  • Prof. Shiriki Kumanyika
• 29 min
  9. The developmental origins of obesity

  • Prof. David Barker
• Consequences of Obesity
• 46 min
  10. Obesity, dyslipoproteinemia and inflammation

  • Prof. Robert Eckel
• 23 min
  11. Pathophysiology and management of obesity related hypertension

  • Prof. Arya Sharma
• 22 min
  12. Disorders of overeating

  • Prof. Albert Stunkard
• 20 min
  13. Obesity, weight loss and health-related quality of life

  • Prof. Aila Rissanen
  • Dr. Jarmo Kaukua
• Treatment Options
• 44 min
  14. Lifestyle modification for weight control

  • Prof. Thomas Wadden
• 34 min
  15. Bariatric / obesity surgery

  • Prof. Henry Buchwald
• 48 min
  16. Can obesity be prevented in the current obesogenic environment?

  • Prof. Boyd Swinburn
• 28 min
  17. Pharmacotherapy for obesity: why it is needed

  • Prof. Joe Proietto
• 35 min
  18. Pharmacotherapy for obesity: hunger suppressors

  • Prof. Joe Proietto
• Latest Developments in the Field
• 60 min
  19. Body composition

  • Dr. Steven Heymsfield
• 56 min
  20. Adipose tissue metabolism and obesity

  • Dr. Max Lafontan
• 25 min
  21. Obesity, present and future therapies

  • Prof. Sir Stephen Bloom
• 42 min
  22. Energy expenditure in the lean and obese

  • Prof. Dale Schoeller
• 33 min
  23. Obesity and adiponectin

  • Prof. Philipp Scherer
• 44 min
  24. Ectopic fat: causes, consequences and treatment

  • Prof. Steven Smith
• 47 min
  25. Adipose-immune interactions in obesity

  • Dr. Vishwa Dixit
• 39 min
  26. Health benefits of intentional weight loss

  • Prof. Xavier Pi-Sunyer
• 39 min
  27. Childhood obesity: implications for current and future health

  • Prof. Peter T. Katzmarzyk
• 46 min
  28. The clinical assessment and management of child and adolescent obesity

  • Prof. Louise Baur
• Archived Lectures - These lectures may not cover the latest advances in the field
• 41 min
  29. Gastrointestinal peptides and food intake regulation

  • Prof. Sir Stephen Bloom
• 48 min
  30. Obesity and mortality: questions and controversy

  • Prof. David Allison
• 37 min
  31. Obesity, diabetes and the cluster of the metabolic syndrome

  • Prof. Peter Wilson
• 44 min
  32. New standards in weight management: recent and future drugs for the treatment of obesity

  • Prof. Luc Van Gaal
• 46 min
  33. Health economics of obesity: new insights

  • Dr. Anne Wolf
• 34 min
  34. Bariatric surgery: techniques and mechanisms of action

  • Prof. Walter Pories
• 39 min
  35. Childhood obesity: implications for future health

  • Prof. Peter T. Katzmarzyk
• 14 min
  36. Pharmacotherapy for obesity 1 - the need for pharmacotherapy in weight management

  • Prof. Joe Proietto
• 46 min
  37. Pharmacotherapy for obesity 2 - pharmacological agents in current use & under development

  • Prof. Joe Proietto

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Topics
3. Ectopic fat
4. Framework of organs interaction (1)
5. Topics - consequences of excess lipid storage
6. Consequences of 'ectopic' fat
7. Lipid oversupply is also referred to as lipotoxicity
8. Ectopic fat and insulin resistance
9. Intramyocellular distribution of lipid droplets
10. Skeletal muscle lipid content
11. The obese and endurance-trained paradox
12. IMCL content and insulin sensitivity
13. Two routes to increased intramyocellular lipid
14. Ectopic fat and the beta cell (1)
15. 'Starling curve' of the pancreas
16. New beta cells are constantly being created
17. Apoptosis is a major factor of beta-cell failure (1)
18. Apoptosis is a major factor of beta-cell failure (2)
19. Ectopic fat and the beta cell (2)
20. Ectopic fat and the liver
21. Liver fat and hepatic insulin resistance
22. Hepatic lipid content related to insulin sensitivity
23. Consequences of hepatic steatosis
24. Topics - causes of ectopic fat
25. Adipose tissue 'dysfunction'
26. Consequences of increased adipose tissue mass
27. The 'adipokine' secretion pattern changes
28. Signal molecules secreted by adipose tissue
29. Adipose tissue 'inflammation'
30. Number of fat cells and the energy 'burden'
31. Large fat cells - a marker of insulin resistance
32. Risk factors for type 2 diabetes
33. Transgenic animal models support Danforth theory
34. Visceral fat is the 'other' ectopic adipose tissue
35. Fat pattern in female and risk of type 2 diabetes
36. Adipose tissue is a complex organ
37. Waist circumference
38. Abdominal adipose tissue - nomenclature
39. Subcutaneous adipose tissue
40. Topics - impairments in fat oxidation
41. Response of the tissues to increased lipid supply
42. Insulin resistance and muscle ATP synthesis
43. Rationale for the study of muscle mitochondria
44. Reduced mitochondrial volume in T2DM
45. Pre-clinical models
46. Topics - ectopic fat treatment
47. Framework of organs interaction (2)
48. Modest weight loss reverses ectopic fat
49. Exercise vs. weight loss
50. Framework - TZDs and 'ectopic' fat
51. Treatment
52. TZD's and ectopic lipid
53. TZDs decrease liver fat
54. Pio increases insulin sensitivity and adiponectin
55. FFA reductions are sufficient to reduce lipotoxicity
56. Summary
57. Thank you
58. Acknowledgements

Topics Covered

• Definition of ectopic fat
• Consequences of ectopic fat
• Insulin resistance
• Beta cell failure
• Increased VLDC cholesterol production / atherogenic dyslipidemia
• Adipose tissue dysfunction
• Adipose tissue inflammation
• An inadequate number of fat cells compared to the energy 'burden'
• Large fat cells
• insulin resistance
• Transgenic animal models
• Visceral fat is the 'other' ectopic adipose tissue
• Adipose tissue is a complex organ
• there is still room for discovery at many levels
• Waist circumference
• Abdominal adipose tissue; nomenclature
• Subcutaneous adipose tissue: radiographic considerations
• The study of muscle mitochondria
• Pre-clinical models
• Modest weight loss reverses ectopic fat
• Exercise vs. weight loss
• Treatment
• TZD's and ectopic lipid

Links

Series:

• Obesity

Categories:

• Clinical Practice
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on April 30, 2009

Financial Disclosures

• Prof. Steven Smith has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.