• The Basics of Microarrays
• 42 min
  1. How to design a successful microarray experiment

  • Dr. Rainer Breitling
• Microarrays in the Understanding of the Biology of the Cell and Whole Organism
• 51 min
  2. Genome-wide mapping of estrogen: receptor binding sites and activity

  • Prof. Jason Carroll
• Microarrays in the Diagnosis, Prognosis and Treatment of Disease
• 35 min
  3. Single nucleotide polymorphism microarrays in the analysis of cancer

  • Dr. Rameen Beroukhim
• Archived Lectures *These may not cover the latest advances in the field
• 23 min
  4. The use of statistics in microarray studies

  • Dr. Ernst Wit
• 42 min
  5. Simultaneous microarray measurement of nuclear and whole cell changes in gene expression reveals overlapping but distinct patterns of transcriptional regulation

  • Dr. Chris Cheadle
• 38 min
  6. Global analysis of gene translation

  • Prof. Philip Tofilon
• 36 min
  7. Microarrays in the study of the basic mechanisms of evolution

  • Dr. Greg Gibson
• 41 min
  8. The use of microarrays to understand the biology and toxicology of low dose arsenic

  • Prof. Joshua Hamilton
• 46 min
  9. The bioinformatics of microarrays

  • Dr. Maureen Sartor
• 44 min
  10. Genome-wide profiling of microRNAs: from scientist benchside to patient bedside

  • Prof. George Calin
• 42 min
  11. Microarrays: their design and use

  • Prof. Craig R. Tomlinson
• 67 min
  12. Cancer systems biology: dissection and analysis of context-specific molecular interaction networks

  • Prof. Andrea Califano
• 35 min
  13. Utilizing microarrays to study posttranscriptional regulatory mechanisms of plants

  • Dr. Brian Gregory

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Talk objectives
3. Replication and sampling
4. 2-color and 1-color designs
5. Volcano plots
6. Linear models and ANOVA
7. Hierarchical clustering
8. Human primate comparison (1)
9. Human primate comparison (2)
10. Human primate comparison (3)
11. Human primate comparison (4)
12. Speciation (1)
13. Speciation (2)
14. Adaptation (1)
15. Adaptation (2)
16. Adaptation (3)
17. Expression variation (1)
18. Expression variation (2)
19. Expression variation (3)
20. An eye to the next few years

Topics Covered

• Gene expression profiling has quickly emerged as an important tool in the study of evolutionary biology
• Many of the statistical methods used in quantitative genetics have been adopted for general use in microarray analysis, while advances in comparative genetics through genome sequencing have enabled comparative functional studies within and among species
• The methodological issues and approaches to microarray-based studies in the context of evolution
• Key studies that have shed light on the conservation and divergence in gene expression between species
• Mechanisms of speciation and hybrid incompatibility
• Natural selection and adaptation
• Linking genotypes to phenotypes via gene expression
• Ecological genetics
• Emerging new types of microarray, and the novel questions they may be used to address

Links

Series:

• Microarrays

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on March 30, 2009
• Archived on February 25, 2021

Financial Disclosures

• Dr. Greg Gibson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.