• The Notion of Epigenetics
• 43 min
  1. Cytoplasmic epigenetics: inheritance by cytoplasmic continuity

  • Prof. Philippe Silar
  • Dr. Fabienne Malagnac
• Epigenetics: Paradigms
• 38 min
  2. The molecular mechanism of X chromosome inactivation

  • Prof. Neil Brockdorff
• 29 min
  3. Genomic imprinting: history and embryology

  • Prof. Davor Solter
• 48 min
  4. X chromosome inactivation in human cells

  • Prof. Barbara Migeon
• 41 min
  5. RNAi and heterochromatin in plants and fission yeast

  • Prof. Robert Martienssen
• Epigenetics: Mechanisms
• 23 min
  6. Polycomb epigenetic mechanisms: role of PcG complexes

  • Prof. Vincenzo Pirrotta
• 29 min
  7. Polycomb epigenetic mechanisms: methylation of DNA

  • Prof. Vincenzo Pirrotta
• 56 min
  8. Histone modifications and prospects for an epigenetic code

  • Prof. Bryan Turner
• 68 min
  9. Epigenetic control by histone methylation

  • Prof. Thomas Jenuwein
• 38 min
  10. Histone dynamics, heritability and variants

  • Dr. Genevieve Almouzni
• 51 min
  11. Gene silencing in budding yeast

  • Prof. Susan Gasser
• Epigenetics: Heritability and Reversibility
• 51 min
  12. Nuclear cloning, stem cells and epigenetic reprogramming

  • Prof. Rudolf Jaenisch
• 64 min
  13. Stem cell memory

  • Prof. James Sherley
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  14. Epigenetics: a historical overview

  • Dr. Robin Holliday
• 43 min
  15. DNA methylation

  • Prof. Adrian Bird
• 45 min
  16. DNA methylation and genome defense in Neurospora crassa

  • Prof. Eric Selker
• 34 min
  17. A historical perspective on ideas on X-chromosome inactivation

  • Dr. Mary Lyon
• 40 min
  18. Evolution of mammal epigenetic control systems

  • Prof. Jenny Graves
• 60 min
  19. Genomic imprinting and its regulation

  • Dr. Anne Ferguson-Smith
• 40 min
  20. Nuclear organization and gene expression

  • Prof. David Spector
• 39 min
  21. Germ cells

  • Prof. Azim Surani
• 41 min
  22. Epigenetic regulation of phenotype

  • Prof. Emma Whitelaw
• 68 min
  23. Epigenetically mediated gene silencing: a companion to genetic alterations in driving tumorigenesis

  • Prof. Stephen Baylin
• 36 min
  24. Cytoplasmic epigenetics: proteins acting as genes

  • Prof. Reed Wickner

Printable Handouts

PDF

Navigable Slide Index

1. Title slide
2. Imprinted gene schematic
3. Talk contents
4. Title slide for classic embryological studies
5. Genetic reconstitution of mouse embryos
6. Androgenetic and parthenogenetic embryos
7. Process of cell insertion
8. Control and chimeric embryos
9. Summary slide
10. Introduction to classic genetic studies
11. Uniparental disomy schematic
12. Uniparental disomy embryos
13. Harwell map
14. Identification of imprinted genes
15. Harwell map with imprinted genes
16. Imprinted genes are clustered
17. Introduction to mechanism
18. DNA methylation and histone modification
19. Properties of an imprint
20. Germline reprogramming
21. DNA methylation fulfils criteria
22. Methylation details
23. Germline reprogramming schematic
24. Introduction to methylation experiments
25. Identifying differential methylation
26. Methylation at an imprinted domain
27. The DLK-dio3 region
28. Harwell map with genes
29. IGF2R receptor
30. Harwell map with genes
31. KCNQ1 locus
32. Harwell map with genes
33. H19/IGF2 domain
34. CTCF/HI20
35. Two different types of imprint
36. Summary
37. Histone modifications
38. Can histone modifications imprint?
39. H4 acetylation
40. H3 modification
41. Histone summary
42. Intorduction to clinical
43. Man mouse homology
44. Man mouse homology table
45. Introduction to worksheet
46. Worksheets tips
47. Worksheet questions
48. Worksheets tips

Topics Covered

• Introduction to imprinting
• classic embryological and genetic studies
• identification and function of imprinted genes
• imprinted domains and the organisation of imprinted clusters
• epigenetic modifications and genome programming
• cis-acting control at imprinted domains
• DNA methylation and non-coding RNA
• histone modifications
• clinical implications

Links

Series:

• Epigenetics

Categories:

• Biochemistry
• Cell Biology
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Dr. Anne Ferguson-Smith has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.