• Epidemiology and Risk Factors
• 23 min
  1. Coronary heart disease epidemiology: global context for a new genetic understanding

  • Prof. Harry Hemingway
• 44 min
  2. Cardiovascular risk factors

  • Dr. Michal Vrablik
• 65 min
  3. Lipoproteins

  • Prof. Arnold von Eckardstein
• 39 min
  4. Thrombotic risk factors for cardiovascular disease

  • Prof. Gordon Lowe
• 20 min
  5. Lipoprotein(a)

  • Dr. Jaimini Cegla
• Biology of Coronary Heart Disease
• 42 min
  6. Plaque rupture

  • Prof. Petri Kovanen
• 56 min
  7. Transcription factors and complex disease development

  • Dr. Ines Pineda-Torra
• 39 min
  8. Animal models to explore cardiovascular disease

  • Prof. Martin Merkel
• Treatment
• 26 min
  9. Diagnosis and treatment of dyslipidemias

  • Prof. Anton Stalenhoef
• 31 min
  10. Key drug discovery challenges in cardiovascular medicine

  • Dr. Dan Swerdlow
  • Dr. Michael V. Holmes
• Genetics
• 50 min
  11. Moving from GWAS hits to functional variants

  • Prof. Steve Humphries
• 51 min
  12. Heart disease genes and SNPs

  • Prof. Steve Humphries
• 39 min
  13. Familial hypercholesterolaemia: genetic causes and treatment

  • Prof. Steve Humphries
• 22 min
  14. Familial hypercholesterolaemia: cascade testing and monogenic vs. polygenic causes

  • Prof. Steve Humphries
• 28 min
  15. Familial hypercholesterolaemia: case studies, universal screening and novel mutations

  • Prof. Steve Humphries
• 52 min
  16. Genetics of cardiovascular disease

  • Prof. Philippa Talmud
• 54 min
  17. The genetics of CHD: moving research findings into patient benefit

  • Prof. Steve Humphries
• 35 min
  18. Mendelian randomisation: using genetics to determine causality

  • Dr. Tina Shah
• 33 min
  19. The genetics of abdominal aortic aneurysm

  • Dr. Seamus Harrison
• 49 min
  20. Genome scans for hypertension

  • Prof. Patricia Munroe
• 43 min
  21. Telomeres and cardiovascular disease

  • Dr. Jess Buxton
• 33 min
  22. Translational applications of cardiovascular genomics: opportunities and challenges

  • Dr. Aroon Hingorani
• 26 min
  23. Genetics of hypertrophic cardiomyopathy (HCM)

  • Dr. Petros Syrris
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  24. Gene-environment interaction and oxidative stress in cardiovascular disease

  • Dr. Jeffrey Stephens
• 34 min
  25. Gene therapy as a therapeutic option for lipoprotein lipase deficiency

  • Dr. Jan Albert Kuivenhoven
• 60 min
  26. Cardiovascular diseases: from epidemiology to nutritional interventions

  • Dr. Antonis Zampelas
• 45 min
  27. Genetic testing for CHD risk: fact or fiction?

  • Prof. Steve Humphries
• 35 min
  28. Pharmacogenetics: progress, pitfalls and clinical potential

  • Prof. Steve Humphries
• 50 min
  29. Familial hyperchlolesterolaemia: a monogenic cause of early CHD

  • Prof. Steve Humphries
• 29 min
  30. Lipid metabolism

  • Dr. Ulrike Beisiegel

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Introduction (2)
3. Problems with current risk factors
4. Effects of risk factors on CVD mortality
5. Prediction of CHD in diabetes
6. Oxidative stress and cardiovascular risk
7. Molecular consequences of oxidative stress
8. The polygenic nature of CHD
9. Gene environment interaction
10. Genes load the gun, environment pulls the trigger
11. Genetic & biochemical markers of oxidative stress
12. Aim of this presentation
13. Measurement of oxidative stress
14. Plasma Total Antioxidant Status (TAOS)
15. Mitochondrial uncoupling protein 2
16. A novel antioxidant UCP2 ?
17. Mitochondria are major source of cellular ROS
18. UCL-diabetes and cardiovascular disease study
19. Northwick park heart study II
20. Prospective CHD risk by plasma TAOS in NPHSII
21. UCP2 common variants
22. Plasma TAOS and UCP2 -866G>A genotype
23. Oxidative stress and UCP2 -866G>A genotype
24. Plasma TAOS, smoking, and UCP2 -866G>A
25. UCP2 genotype and CHD risk in NPHSII
26. Other CHD risk factors
27. The important of UCP2
28. UCP2 environment interaction and CHD risk
29. Does statin treatment reduce oxidative stress?
30. Apolipoprotein E (APOE)
31. APOE and CHD risk
32. APOE genotype and CHD risk
33. APOE and oxidative stress
34. The APOE genotype interaction with smoking
35. Glutathione s-transferase gene (GST)
36. GSTs and oxidative stress
37. The role of glutathione s-transferase
38. GST gene variants
39. GST gene variants and CVD
40. Plasma Ox-LDL by GSTT1 genotype & smoking
41. Other gene variants (1)
42. Other gene variants (2)
43. Summary overview
44. Acknowledgments

Topics Covered

• Oxidative stress: a risk factor for CVD
• Biochemical markers of oxidative stress
• Genetic determinants of oxidative stress: examples
• Examples of gene-environment interaction in determining oxidative stress and CVD
• Other gene variants and oxidative stress

Links

Series:

• Genetics of Cardiovascular Disease

Categories:

• Clinical Practice
• Genetics & Epigenetics

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on November 24, 2008
• Archived on February 25, 2021

Financial Disclosures

• Dr. Jeffrey Stephens has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.