• Epidemiology and Risk Factors
• 23 min
  1. Coronary heart disease epidemiology: global context for a new genetic understanding

  • Prof. Harry Hemingway
• 44 min
  2. Cardiovascular risk factors

  • Dr. Michal Vrablik
• 65 min
  3. Lipoproteins

  • Prof. Arnold von Eckardstein
• 39 min
  4. Thrombotic risk factors for cardiovascular disease

  • Prof. Gordon Lowe
• 20 min
  5. Lipoprotein(a)

  • Dr. Jaimini Cegla
• Biology of Coronary Heart Disease
• 42 min
  6. Plaque rupture

  • Prof. Petri Kovanen
• 56 min
  7. Transcription factors and complex disease development

  • Dr. Ines Pineda-Torra
• 39 min
  8. Animal models to explore cardiovascular disease

  • Prof. Martin Merkel
• Treatment
• 26 min
  9. Diagnosis and treatment of dyslipidemias

  • Prof. Anton Stalenhoef
• 31 min
  10. Key drug discovery challenges in cardiovascular medicine

  • Dr. Dan Swerdlow
  • Dr. Michael V. Holmes
• Genetics
• 50 min
  11. Moving from GWAS hits to functional variants

  • Prof. Steve Humphries
• 51 min
  12. Heart disease genes and SNPs

  • Prof. Steve Humphries
• 39 min
  13. Familial hypercholesterolaemia: genetic causes and treatment

  • Prof. Steve Humphries
• 22 min
  14. Familial hypercholesterolaemia: cascade testing and monogenic vs. polygenic causes

  • Prof. Steve Humphries
• 28 min
  15. Familial hypercholesterolaemia: case studies, universal screening and novel mutations

  • Prof. Steve Humphries
• 52 min
  16. Genetics of cardiovascular disease

  • Prof. Philippa Talmud
• 54 min
  17. The genetics of CHD: moving research findings into patient benefit

  • Prof. Steve Humphries
• 35 min
  18. Mendelian randomisation: using genetics to determine causality

  • Dr. Tina Shah
• 33 min
  19. The genetics of abdominal aortic aneurysm

  • Dr. Seamus Harrison
• 49 min
  20. Genome scans for hypertension

  • Prof. Patricia Munroe
• 43 min
  21. Telomeres and cardiovascular disease

  • Dr. Jess Buxton
• 33 min
  22. Translational applications of cardiovascular genomics: opportunities and challenges

  • Dr. Aroon Hingorani
• 26 min
  23. Genetics of hypertrophic cardiomyopathy (HCM)

  • Dr. Petros Syrris
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  24. Gene-environment interaction and oxidative stress in cardiovascular disease

  • Dr. Jeffrey Stephens
• 34 min
  25. Gene therapy as a therapeutic option for lipoprotein lipase deficiency

  • Dr. Jan Albert Kuivenhoven
• 60 min
  26. Cardiovascular diseases: from epidemiology to nutritional interventions

  • Dr. Antonis Zampelas
• 45 min
  27. Genetic testing for CHD risk: fact or fiction?

  • Prof. Steve Humphries
• 35 min
  28. Pharmacogenetics: progress, pitfalls and clinical potential

  • Prof. Steve Humphries
• 50 min
  29. Familial hyperchlolesterolaemia: a monogenic cause of early CHD

  • Prof. Steve Humphries
• 29 min
  30. Lipid metabolism

  • Dr. Ulrike Beisiegel

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Inflammation and atherosclerosis - an early start
3. Infection and atherosclerosis
4. Immune activation
5. Response to injury hypothesis
6. Inflammation - the 21st century hypothesis
7. Pathophysiology of atherosclerosis - cholesterol
8. 1914 - the start of the cholesterol era
9. It is the LDL level that counts
10. Arterial intima - the site of atherosclerosis
11. Genesis of thickening intima
12. Adaptive intimal thickening
13. Coronary athero-sclerotic lesions
14. Cholesterol in the blood and coronary arterial wall
15. Coronary artery disease
16. LDL-driven atherosclerosis - negative remodeling
17. Human coronary atheroma
18. LDL-driven atheroma - positive remodeling
19. Real life - both negative and positive remodeling
20. Atherothrombosis
21. Atherothrombosis - the final stage
22. Plaque disruption without luminal thrombosis
23. Plaque disruption - luminal mural thrombosis
24. Plaque disruption - infract related thrombosis
25. Structure of an LDL particle
26. Transcytosis of LDL particles
27. Extracellular matrix of the arterial intima
28. Accumulation of infused human LDL in rabbit
29. Fatty streak formation in fetal aortal intima
30. Adhesion of monocytes to plaque endothel
31. Transmigration of monocytes
32. Macrophage foam cells in the PG rich layer
33. Coronary fatty streak
34. Foam cell between the cap and core of atheroma
35. Coronary fibroatheroma
36. LDL modification in the arterial intima
37. Accumulation of LDL in the arterial intima
38. Oxidants/hydrolases accelerate LDL modification
39. Formation of an early atherosclerotic lesions
40. Regression of a foam cell into a macrophage
41. Lipid core formation
42. Degradation of collagen
43. Summary

Topics Covered

• Inflammation and aetherosclerosis
• Immune activation
• Response to injury hypothesis
• Discovery of the pathophysiology of aetherosclerosis
• The cholesterol era
• The LDL level
• Arterial intima: the site of atherogenesis
• Genesis of thickening intima
• Adaptive intimal thickening
• Topology of coronary athero-sclerotic lesions
• Cholesterol in blood and in coronary arterial wall
• The "bad" LDL cholesterol and the "good" HDL cholesterol: an imbalance
• Coronary artery disease
• LDL-driven atherosclerosis leads to coronary stenosis |Human coronary atheroma
• Atherothrombosis
• Plaque disruption
• Structure of an LDL particle
• Extracellular aggregated and fused LDL particles in the arterial intima of genetically hyperlipidemic mouse
• Extracellular lipid droplets in human atherosclerotic plaque
• Fatty streak formation in human fetal aortas is enchanced by maternal hypercholesterolemia
• Transmigration of monocytes
• Foam cells between cap and core of a coronary atheroma
• Coronary fibroatheroma
• LDL modification in the arterial intima: a vicious circle
• Accumulation of LDL in the arterial intima
• Mast cell neutral proteases activate MMPs
• Degradation of collagen
• Preventing cholesterol accumulation and subsequent inflammation or even more?

Links

Series:

• Genetics of Cardiovascular Disease

Categories:

• Clinical Practice

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on December 18, 2008

Financial Disclosures

• Prof. Petri Kovanen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.