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- Epidemiology and Risk Factors
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23 min
1. Coronary heart disease epidemiology: global context for a new genetic understanding- Prof. Harry Hemingway
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44 min
2. Cardiovascular risk factors- Dr. Michal Vrablik
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65 min
3. Lipoproteins- Prof. Arnold von Eckardstein
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39 min
4. Thrombotic risk factors for cardiovascular disease- Prof. Gordon Lowe
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20 min
5. Lipoprotein(a)- Dr. Jaimini Cegla
- Biology of Coronary Heart Disease
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42 min
6. Plaque rupture- Prof. Petri Kovanen
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56 min
7. Transcription factors and complex disease development- Dr. Ines Pineda-Torra
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39 min
8. Animal models to explore cardiovascular disease- Prof. Martin Merkel
- Treatment
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26 min
9. Diagnosis and treatment of dyslipidemias- Prof. Anton Stalenhoef
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31 min
10. Key drug discovery challenges in cardiovascular medicine- Dr. Dan Swerdlow
- Dr. Michael V. Holmes
- Genetics
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50 min
11. Moving from GWAS hits to functional variants- Prof. Steve Humphries
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51 min
12. Heart disease genes and SNPs- Prof. Steve Humphries
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39 min
13. Familial hypercholesterolaemia: genetic causes and treatment- Prof. Steve Humphries
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22 min
14. Familial hypercholesterolaemia: cascade testing and monogenic vs. polygenic causes- Prof. Steve Humphries
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28 min
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52 min
16. Genetics of cardiovascular disease- Prof. Philippa Talmud
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54 min
17. The genetics of CHD: moving research findings into patient benefit- Prof. Steve Humphries
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35 min
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33 min
19. The genetics of abdominal aortic aneurysm- Dr. Seamus Harrison
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49 min
20. Genome scans for hypertension- Prof. Patricia Munroe
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43 min
21. Telomeres and cardiovascular disease- Dr. Jess Buxton
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33 min
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26 min
23. Genetics of hypertrophic cardiomyopathy (HCM)- Dr. Petros Syrris
- Archived Lectures *These may not cover the latest advances in the field
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44 min
24. Gene-environment interaction and oxidative stress in cardiovascular disease- Dr. Jeffrey Stephens
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34 min
25. Gene therapy as a therapeutic option for lipoprotein lipase deficiency- Dr. Jan Albert Kuivenhoven
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60 min
26. Cardiovascular diseases: from epidemiology to nutritional interventions- Dr. Antonis Zampelas
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45 min
27. Genetic testing for CHD risk: fact or fiction?- Prof. Steve Humphries
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35 min
28. Pharmacogenetics: progress, pitfalls and clinical potential- Prof. Steve Humphries
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50 min
29. Familial hyperchlolesterolaemia: a monogenic cause of early CHD- Prof. Steve Humphries
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29 min
30. Lipid metabolism- Dr. Ulrike Beisiegel
Printable Handouts
Navigable Slide Index
- Introduction
- Inflammation and atherosclerosis - an early start
- Infection and atherosclerosis
- Immune activation
- Response to injury hypothesis
- Inflammation - the 21st century hypothesis
- Pathophysiology of atherosclerosis - cholesterol
- 1914 - the start of the cholesterol era
- It is the LDL level that counts
- Arterial intima - the site of atherosclerosis
- Genesis of thickening intima
- Adaptive intimal thickening
- Coronary athero-sclerotic lesions
- Cholesterol in the blood and coronary arterial wall
- Coronary artery disease
- LDL-driven atherosclerosis - negative remodeling
- Human coronary atheroma
- LDL-driven atheroma - positive remodeling
- Real life - both negative and positive remodeling
- Atherothrombosis
- Atherothrombosis - the final stage
- Plaque disruption without luminal thrombosis
- Plaque disruption - luminal mural thrombosis
- Plaque disruption - infract related thrombosis
- Structure of an LDL particle
- Transcytosis of LDL particles
- Extracellular matrix of the arterial intima
- Accumulation of infused human LDL in rabbit
- Fatty streak formation in fetal aortal intima
- Adhesion of monocytes to plaque endothel
- Transmigration of monocytes
- Macrophage foam cells in the PG rich layer
- Coronary fatty streak
- Foam cell between the cap and core of atheroma
- Coronary fibroatheroma
- LDL modification in the arterial intima
- Accumulation of LDL in the arterial intima
- Oxidants/hydrolases accelerate LDL modification
- Formation of an early atherosclerotic lesions
- Regression of a foam cell into a macrophage
- Lipid core formation
- Degradation of collagen
- Summary
Topics Covered
- Inflammation and aetherosclerosis
- Immune activation
- Response to injury hypothesis
- Discovery of the pathophysiology of aetherosclerosis
- The cholesterol era
- The LDL level
- Arterial intima: the site of atherogenesis
- Genesis of thickening intima
- Adaptive intimal thickening
- Topology of coronary athero-sclerotic lesions
- Cholesterol in blood and in coronary arterial wall
- The "bad" LDL cholesterol and the "good" HDL cholesterol: an imbalance
- Coronary artery disease
- LDL-driven atherosclerosis leads to coronary stenosis |Human coronary atheroma
- Atherothrombosis
- Plaque disruption
- Structure of an LDL particle
- Extracellular aggregated and fused LDL particles in the arterial intima of genetically hyperlipidemic mouse
- Extracellular lipid droplets in human atherosclerotic plaque
- Fatty streak formation in human fetal aortas is enchanced by maternal hypercholesterolemia
- Transmigration of monocytes
- Foam cells between cap and core of a coronary atheroma
- Coronary fibroatheroma
- LDL modification in the arterial intima: a vicious circle
- Accumulation of LDL in the arterial intima
- Mast cell neutral proteases activate MMPs
- Degradation of collagen
- Preventing cholesterol accumulation and subsequent inflammation or even more?
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Kovanen, P. (2008, December 18). Plaque rupture [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 20, 2025, from https://doi.org/10.69645/MHSC4633.Export Citation (RIS)
Publication History
- Published on December 18, 2008
Financial Disclosures
- Prof. Petri Kovanen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
