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- Epidemiology and Risk Factors
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1. Coronary heart disease epidemiology: global context for a new genetic understanding
- Prof. Harry Hemingway
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2. Cardiovascular risk factors
- Dr. Michal Vrablik
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3. Lipoproteins
- Prof. Arnold von Eckardstein
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4. Thrombotic risk factors for cardiovascular disease
- Prof. Gordon Lowe
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5. Lipoprotein(a)
- Dr. Jaimini Cegla
- Biology of Coronary Heart Disease
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6. Plaque rupture
- Prof. Petri Kovanen
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7. Transcription factors and complex disease development
- Dr. Ines Pineda-Torra
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8. Animal models to explore cardiovascular disease
- Prof. Martin Merkel
- Treatment
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9. Diagnosis and treatment of dyslipidemias
- Prof. Anton Stalenhoef
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10. Key drug discovery challenges in cardiovascular medicine
- Dr. Dan Swerdlow
- Dr. Michael V. Holmes
- Genetics
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11. Moving from GWAS hits to functional variants
- Prof. Steve Humphries
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12. Heart disease genes and SNPs
- Prof. Steve Humphries
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13. Familial hypercholesterolaemia: genetic causes and treatment
- Prof. Steve Humphries
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14. Familial hypercholesterolaemia: cascade testing and monogenic vs. polygenic causes
- Prof. Steve Humphries
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16. Genetics of cardiovascular disease
- Prof. Philippa Talmud
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17. The genetics of CHD: moving research findings into patient benefit
- Prof. Steve Humphries
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19. The genetics of abdominal aortic aneurysm
- Dr. Seamus Harrison
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20. Genome scans for hypertension
- Prof. Patricia Munroe
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21. Telomeres and cardiovascular disease
- Dr. Jess Buxton
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23. Genetics of hypertrophic cardiomyopathy (HCM)
- Dr. Petros Syrris
- Archived Lectures *These may not cover the latest advances in the field
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24. Gene-environment interaction and oxidative stress in cardiovascular disease
- Dr. Jeffrey Stephens
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25. Gene therapy as a therapeutic option for lipoprotein lipase deficiency
- Dr. Jan Albert Kuivenhoven
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26. Cardiovascular diseases: from epidemiology to nutritional interventions
- Dr. Antonis Zampelas
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27. Genetic testing for CHD risk: fact or fiction?
- Prof. Steve Humphries
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28. Pharmacogenetics: progress, pitfalls and clinical potential
- Prof. Steve Humphries
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29. Familial hyperchlolesterolaemia: a monogenic cause of early CHD
- Prof. Steve Humphries
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30. Lipid metabolism
- Dr. Ulrike Beisiegel
Printable Handouts
Navigable Slide Index
- Introduction
- Lipids
- Functions of lipids
- Outline (1)
- Lipid absorption in the intestine
- Intestinal sterol uptake
- Intestinal fatty acid uptake
- Intestinal chylomicron formation
- Postprandial hyperlipidemia
- Lipoprotein model
- Major lipoproteins and apoproteins
- Apo B100 and Apo B48 are derived from one gene
- Postprandial lipoprotein metabolism
- Insulin as a major postprandial hormone
- Metabolism of adipose tissue
- Nutritional lipids are also delivered to the bone
- CR deliver lipids and vitamin K to the bone
- Outline (2)
- Hepatic lipid metabolism
- Hepatic receptors for lipoprotein uptake
- CR uptake into the liver
- Hepatic lipoprotein pathways
- Size of VLDL determines LDL size
- Role of apo E in lipoprotein catabolism
- Apo E polymorphism
- Outline (3)
- LDL receptor a key player in cellular homeostasis
- Intracellular cholesterol regulated gene expression
- Outline (4)
- Reverse cholesterol transport by HDL
- Lipid exchange proteins
- Normal levels for plasmalipids
- Dietary lipids
- Thank you
Topics Covered
- Functions of lipids
- Lipid absorption in the intestine
- Intestinal sterol and fatty acid uptake
- Intestinal chylomicron formation
- Postprandial hyperlipidemia
- Lipoprotein model
- Major lipoproteins and apoproteins
- Postprandial lipoprotein metabolism
- Insulin as major postprandial hormone
- Metabolism of adipose tissue
- Nutritional lipids are also delivered to the bone
- Chylomicron remnants deliver lipids and vitamin K to the bone
- Hepatic lipid metabolism
- What are the receptors responsible for CR uptake?
- CR uptake into the liver
- Hepatic lipoprotein pathways
- Size of VLDL determines LDL size
- Role of apo E in lipoprotein catabolism
- Apo E polymorphism
- Cellular cholesterol homeostasis
- LDL receptor involved in cellular cholesterol homeostasis
- Intracellular cholesterol regulated gene expression
- 'Reverse cholesterol transport' by HDL
- Lipid exchange proteins
- Normal levels for plasmalipids
- Dietary lipids
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Beisiegel, U. (2008, December 15). Lipid metabolism [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 20, 2025, from https://doi.org/10.69645/VEED1634.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Ulrike Beisiegel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.