• The Notion of Epigenetics
• 43 min
  1. Cytoplasmic epigenetics: inheritance by cytoplasmic continuity

  • Prof. Philippe Silar
  • Dr. Fabienne Malagnac
• Epigenetics: Paradigms
• 38 min
  2. The molecular mechanism of X chromosome inactivation

  • Prof. Neil Brockdorff
• 29 min
  3. Genomic imprinting: history and embryology

  • Prof. Davor Solter
• 48 min
  4. X chromosome inactivation in human cells

  • Prof. Barbara Migeon
• 41 min
  5. RNAi and heterochromatin in plants and fission yeast

  • Prof. Robert Martienssen
• Epigenetics: Mechanisms
• 23 min
  6. Polycomb epigenetic mechanisms: role of PcG complexes

  • Prof. Vincenzo Pirrotta
• 29 min
  7. Polycomb epigenetic mechanisms: methylation of DNA

  • Prof. Vincenzo Pirrotta
• 56 min
  8. Histone modifications and prospects for an epigenetic code

  • Prof. Bryan Turner
• 68 min
  9. Epigenetic control by histone methylation

  • Prof. Thomas Jenuwein
• 38 min
  10. Histone dynamics, heritability and variants

  • Dr. Genevieve Almouzni
• 51 min
  11. Gene silencing in budding yeast

  • Prof. Susan Gasser
• Epigenetics: Heritability and Reversibility
• 51 min
  12. Nuclear cloning, stem cells and epigenetic reprogramming

  • Prof. Rudolf Jaenisch
• 64 min
  13. Stem cell memory

  • Prof. James Sherley
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  14. Epigenetics: a historical overview

  • Dr. Robin Holliday
• 43 min
  15. DNA methylation

  • Prof. Adrian Bird
• 45 min
  16. DNA methylation and genome defense in Neurospora crassa

  • Prof. Eric Selker
• 34 min
  17. A historical perspective on ideas on X-chromosome inactivation

  • Dr. Mary Lyon
• 40 min
  18. Evolution of mammal epigenetic control systems

  • Prof. Jenny Graves
• 60 min
  19. Genomic imprinting and its regulation

  • Dr. Anne Ferguson-Smith
• 40 min
  20. Nuclear organization and gene expression

  • Prof. David Spector
• 39 min
  21. Germ cells

  • Prof. Azim Surani
• 41 min
  22. Epigenetic regulation of phenotype

  • Prof. Emma Whitelaw
• 68 min
  23. Epigenetically mediated gene silencing: a companion to genetic alterations in driving tumorigenesis

  • Prof. Stephen Baylin
• 36 min
  24. Cytoplasmic epigenetics: proteins acting as genes

  • Prof. Reed Wickner

Printable Handouts

PDF

Navigable Slide Index

1. Epigenetics - introduction
2. Rival hypotheses
3. Thomas Hunt Morgan
4. CH Waddington
5. Ernst Hadorn
6. 3 development features that demand explanation
7. Arthur Riggs
8. DNA methylation
9. Evidence for methylation
10. Isoschizomers and 5-aza-cytidine
11. Definitions of epigenetics
12. "Dual inheritance"
13. Mechanisms other than DNA methylation
14. The epigenome project
15. Summary

Topics Covered

• Introduction to epigenetics
• the leading pioneers in the field of epigenetics
• the basic features of development
• switching and heritability of gene activities
• DNA methylation
• epimutations
• differences between genetics and epigenetics
• genomic imprinting
• chromatin structure
• histone modifications
• the role of RNA in the epigenetic regulation of gene activity
• the bisulfite sequencing technique
• the epigenotype

Links

Series:

• Epigenetics

Categories:

• Biochemistry
• Cell Biology
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007
• Reviewed on August 12, 2020
• Archived on October 21, 2020

Financial Disclosures

• Dr. Robin Holliday has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.