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Gene-Environment InteractionsRole in the Modulation of Pulmonary and Autoimmune Disease Risks

Launched October 2007 Updated January 2022 18 lectures
Summary

It is well established that the environment can have a profound effect on gene expression. Classical examples are the influence of temperature on sex in some reptiles and colouring in Siamese cats. An active area of medical research is the respective contributions of genes and the environment in common complex... read morediseases and therapeutic intervention.

Several common pulmonary diseases, such as asthma, COPD and pneumoconiosis, as well as autoimmune diffuse connective tissue diseases, such as systemic lupus erythematosus (SLE; lupus) and systemic sclerosis (scleroderma, progressive systemic sclerosis), are thought to involve both genes influencing susceptibility and, environmental factors. In addition, disease susceptibility and expression for these and other groups of diseases may display significant racial and ethnic variation in human populations.

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Statistical Genetics of Complex Diseases (4 Lectures)  

Molecular Epidemiology of Pulmonary Diseases (2 Lectures)  

Autoimmune Diffuse Connective Tissue Diseases (1 Lecture)  

Drug-Induced Disease (1 Lecture)  

Archived Lectures *These may not cover the latest advances in the field (10 Lectures)  

Biomarkers of exposure
41 min
  • Prof. Thomas Smith
  • Exposure, Epidemiology and Risk Program, Harvard School of Public Health
Archived
GIS and spatial statistics
43 min
  • Prof. Louise Ryan
  • Department of Biostatistics, Harvard School of Public Health, USA
Archived
Gene-by-environment interactions in COPD
47 min
  • Prof. Edwin Silverman
  • Channing Laboratory and Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, USA
Archived
Occupational and environmental influences on the development and course of lupus
40 min
  • Dr. Glinda Cooper
  • National Center for Environmental Assessment, US Environmental Protection Agency
Archived
Genetic susceptibility in granulomatous disorders: chronic beryllium disease and sarcoidosis
54 min
  • Prof. Lee Newman
  • University of Colorado at Denver and Health Sciences Center
Archived
Indians, twins and scleroderma: genetic and genomic studies
29 min
  • Prof. Frank Arnett
  • University of Texas Medical School at Houston, USA
Archived
Gene by environment interaction in asthma
27 min
  • Prof. Scott Weiss
  • Channing Laboratory, Harvard Medical School
Archived
Molecular epidemiology of lung cancer
42 min
  • Prof. David Christiani
  • Harvard School of Public Health and Harvard Medical School, USA
Archived
Racial and ethnic variation in systemic lupus erythematosus and systemic sclerosis (scleroderma)
18 min
  • Dr. Patricia Fraser
  • CBR Institute for Biomedical Research and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Associate Professor of Medicine, Harvard Medical School, USA
Archived
Infectious environmental factors and systemic lupus erythematosus
47 min
  • Prof. Judith James
  • Oklahoma Medical Research Foundation
Archived