Environmental scleroderma: the evidence for putative triggers

Published on October 1, 2007 Updated on January 31, 2018   29 min

Other Talks in the Category: Diseases, Disorders & Treatments

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This is Professor Maureen Mayes from the Division of Rheumatology at the McGovern Medical School, University of Texas in Houston, Texas talking about Environmental Scleroderma: The Evidence for External Triggers.
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Scleroderma or systemic sclerosis is a chronic auto immune disease characterized by widespread fibrosis in the skin and internal organs. There are also a non-inflammatory small vessel vasculopathy with Raynaud's phenomenon as a major manifestation, frequently leading to a scheme like Digital Tip ulcers and also associated with a sudden increase in blood pressure known as scleroderma renal crisis, that if untreated, can result in renal failure. In addition to these features, there is evidence of immune activation with the presence of scleroderma specific autoantibodies in many but not all cases.
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As is true for all autoimmune diseases, the cause is unknown. It is assumed, however, that the disease occurs as a result of some environmental exposure acting on a genetically susceptible host. The nature of this exposure is unknown but in the correct genetically susceptible host, these agents could include any number of bacterial or viral infections as well as occupational or other chemical exposures, including toxins and allergens resulting in the condition we call scleroderma.
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Environmental scleroderma: the evidence for putative triggers

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