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Printable Handouts
Navigable Slide Index
- Introduction
- BBB is an impediment in CNS drug development
- CNS drug development
- The evolving concept of the blood-brain barrier
- Neurovascular unit as an integrated concept
- Tight junctions form the 'physical' barrier
- The transport systems of the blood-brain barrier
- Strategies to deliver drugs into the brain (1)
- Strategies to deliver drugs into the brain (2)
- Strategies to deliver drugs into the brain (3)
- Routes for drug delivery across the BBB
- Transcellular lipophilic diffusion
- Inhibition of efflux pumps
- Paracellular hydrophilic diffusion
- Carrier-mediated transport
- Adsorptive endocytosis
- Receptor-mediated transcytosis
- The molecular 'Trojan horses' concept
- 'Trojan horses'
- HIR as a 'Trojan horse' for drug delivery to the brain
- 'Trojan horses' and nanocarriers
- Considerations in designing 'Trojan horses'
- Discovery and development of novel 'Trojan horses'
- Single domain antibodies
- Single-domain antibody phage display libraries
- Selection of the BBB - targeting sdAbs
- Brain-targeting single-domain antibodies
- Mechanisms of transport
- Linking molecules to FC5
- In vivo biodistribution of FC5
- Improving FC5 pharmacokinetics
- Brain accumulation of FC5 formulations
- Detection of FC5 in brain tissues
- Detection of FC5 by confocal microscopy (1)
- Detection of FC5 by confocal microscopy (2)
- Summary
- FC5-functionalized liposomes
- Delivery using FC5-functionalized liposomes (1)
- Delivery using FC5-functionalized liposomes (2)
- Tailoring BBB delivery strategies (1)
- Tailoring BBB delivery strategies (2)
Topics Covered
- Restrictive nature of the blood-brain barrier
- Non-vascular routes for brain drug delivery
- Vascular routes for brain drug delivery
- Concept of Trojan horses
- Discovery of novel receptor-mediated transcytosis routes across the blood-brain barrier
- Principles of blood-brain barrier vector development in experimental models
Links
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Talk Citation
Stanimirovic, D. (2008, March 1). The blood-brain barrier and CNS drug development [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 22, 2024, from https://doi.org/10.69645/GGED9050.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Danica Stanimirovic has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.