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Printable Handouts
Navigable Slide Index
- Introduction
- Apoptosis and programmed cell death
- Programmed cell death during digit formation
- Features of apoptosis
- Cells undergoing apoptosis
- Apoptosis roles
- Induction of apoptosis by caspases
- Inactive executioner caspase & active caspase
- Destroying the DNA
- Substrate cleavage
- Activation of caspases
- Initiator caspase activation
- Protein-protein interaction domains in caspases
- Death folds
- Inhibitor of apoptosis proteins
- Apoptotic pathways in mammals
- Death receptors
- Pathway of Fas and TRAIL-receptors
- Pathway of TNFR-1
- FLIP inhibits caspase 8 activation
- Mitochondrial pathway of apoptosis
- Cytochrome c release during apoptosis
- Apoptosome
- APAF-1, caspase 9 and cytochrom c mutant mice
- The Bcl-2 family proteins
- Bcl-2 family proteins have similar structures
- Bax and Bak oligomerization
- Activation and repression by Bcl-2 proteins
- MOMP also promotes apoptosis inhibiting XIAP
- BID bridges between apoptotic pathways
- Caspase-independent cell death
- Cells die in the absence of caspase activation
- Interdigital web: caspase independent cell death
- Apoptotic cells are removed from the system
- Phospholipids "scramble" in plasma membrane
- Apoptotic pathways in mammals
Topics Covered
- Apoptosis and programmed cell death
- Apoptosis: developmental signals, damage or stress, loss of adhesion and oncogenesis
- Caspases: inactive and active
- Death folds
- Inhibitors of apoptosis proteins
- Death receptor (extrinsic) pathway
- Mitochondrial (intrinsic) pathway
- The Bcl-2 family proteins
- Apoptosome
- Activation, repression and de-repression
- Caspase-independent cell death
- Cells die in the absence of caspase activation
Talk Citation
Green, D. (2007, October 1). Apoptotic pathways in mammals [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 26, 2024, from https://doi.org/10.69645/LOZV2081.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Douglas Green has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.