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1. Introduction
2. Severe combined immunodeficiency
3. Diseases associated with IL-7R polymorphisms
4. Thymic defect in IL-7R-/- mice
5. Gene therapy of SCID
6. Gene therapy and cancer risk
7. Gamma-c cytokine receptors
8. IL7 receptor knockout
9. IL7 ligand knockout
10. Effect of IL-7 survival of pro-T subsets
11. Bcl-2 family of anti and pro-apoptotic proteins
12. Trophic factor & mitochondrial damage
13. Bcl-2 promotes D1 cell survival
14. Bax deficiency restores T cell development
15. The effect of IL-7 withdrawal
16. IL-7R mutants from human T-ALL
17. Mutant hIL-7R and ligand-independent signaling
18. D1 cells with mutant hIL-7R induce tumors in vivo
19. Mutant IL-7R converts D1 to tumor-forming cells
20. Hematopoietic neoplasm in multiple organs
21. hIL-7Ralpha mutants promote dimerization
22. Mutant IL-7Ralpha model
23. Exon 6 of IL-7Ralpha (1)
24. Exon 6 of IL-7Ralpha (2)
25. Lymphocyte homeostasis
26. Homeostatic correction
27. Resource limitation example (1)
28. Resource limitation example (2)
29. Resource limitation example (3)
30. Resource limitation example (4)
31. Resource limitation example (5)
32. Resource limitation example (6)
33. IL-7 and nave CD8 homeostasis
34. Classical proliferation pathway model
35. IL-7/IL-3 proliferation pathway model (1)
36. IL-7/IL-3 proliferation pathway model (2)
37. IL-7/IL-3 proliferation pathway illustration
38. Thymic cells expressing knock-in IL-7-CFP
39. Class II MHC expression on thymic epithelium
40. Class II MHC expression on skin dendritic cells
41. Developing thymocides grow in a matrix
42. Matrix nature
43. Thymic epithelial cell matrix
44. Looking down through the matrix
45. In the embryonic thymus
46. IL-7-CFP knock-in
47. IL-7 in the bone marrow
48. rhIL-7 increases in vivo TCR repertoire diversity
49. IL-7 drives T cell-cycle entry & expansion in HIV-1
50. Progressive multifocal leukoencephalopathy
51. IL-7 improves survival in sepsis
52. Treatment with IL-7 inhibitors
53. Acknowledgments
54. Producing cytokines painting

Topics Covered

• IL-7 in T cell development
• IL-7R in leukemia
• IL-7 in T cell homeostasis
• IL-7-expressing cells

Links

Series:

• Cytokines

Categories:

• Cancer
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Oncology

Talk Citation

Publication History

• Published on December 18, 2012

Financial Disclosures

• Dr. Scott Durum has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.