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1. Introduction
2. Outline of the presentation
3. Type 1 vs. Type 2 immunity
4. Type 2 immunity - a double-edged sword
5. Development of a type 2 immune response
6. Discovery of innate type 2 effector cells
7. Basophils, mast cells and eosinophils
8. Developmental relationship
9. Detection of basophils by CD49b/IgE staining
10. Nippostrongylus brasiliensis infection
11. N. brasiliensis infected lung
12. N. brasiliensis infected small intestine
13. Analysis of basophil turnover in vivo
14. Activating receptors on basophils
15. Activation of basophils by IgE
16. Cytokine instruction of basophils
17. Basophil effector functions
18. Generation & analysis of basophil-deficient mice
19. Mast cell protease 8 is expressed in basophils
20. Deletion of basophils in Mcpt8Cre mice
21. Mast cells are not deleted in Mcpt8Cre mice
22. Effector function of basophils
23. Are basophils required for Th2 polarization?
24. DCs or basophils for Th2 polarization? (1)
25. Generation of DC-deficient mice
26. DCs or basophils for Th2 polarization? (2)
27. DCs are required for Th2 polarization
28. Role of innate IL-4 for Th2 polarization
29. Innate IL-4/IL-13 regulates Th2 accumulation
30. Basophils in anaphylactic responses
31. IgG1-mediated systemic anaphylaxis
32. Basophils aren't required for anaphylaxis
33. Basophils in chronic allergic inflammation of skin
34. Basophils are required for allergic inflammation
35. Basophil response against helminths and ticks
36. Primary response to N. brasiliensis
37. Expulsion kinetics of N. brasiliensis
38. Protective immunity against N. brasiliensis
39. Basophils during secondary infection
40. Protective immunity against ticks
41. Summary
42. Acknowledgements

Topics Covered

• Relationship of basophils to mast cells and eosinophils
• Development and activation of basophils
• Basophil-deficient mice
• Role of basophils and dendritic cells in Th2 polarization
• Anaphylaxis and allergic skin inflammation
• Basophil response to helminths and ticks

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on April 3, 2012

Financial Disclosures

• Prof. David Voehringer has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.