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1. Introduction
2. Acute myocardial infarction
3. Myocyte death during ischemia
4. Myocyte death during reperfusion
5. ROS and myocardial injury
6. Classification and metabolism of ROS
7. Cellular sources of ROS
8. Pathogenesis of reperfusion injury
9. Study protocol of myocyte death
10. Reperfusion and apoptosis
11. Time course of myocyte death
12. Study protocol of apoptosis
13. Inhibition of apoptosis
14. Apoptosis and cardioprotection
15. Targeting reperfusion injury
16. ROS and postconditioning
17. Algorithm of postconditioning
18. Oxygen level and postconditioning
19. Detection of superoxide radical
20. Reoxygenation and ROS
21. Reduction of superoxide radical
22. Reduction of hydrogen peroxide
23. Mitochondrial calcium overload
24. Mitochondrial dysfunction
25. Reoxygenation and apoptosis
26. Mitochondrial cytochrome c
27. Bcl-2 and Bax expression
28. Intrinsic apoptotic pathways
29. Extrinsic apoptotic pathways
30. Study protocol of antioxidant
31. Antioxidant and ROS
32. MAPKs and apoptosis
33. NF-kappa-B Activation
34. TNF-alpha and IL-6
35. TNF-alpha expression
36. Caspase-3 activity
37. Apoptosis and antioxidant
38. DNA fragmentation
39. Summary of apoptotic death
40. Future directions with antioxidant
41. Acknowledgment

Topics Covered

• Reactive oxygen species
• Ischemia/reperfusion
• Necrosis
• Apoptosis
• Infarct size
• Mitochondrial calcium overload
• Mitochondrial dysfunction
• Cytochrome c release from mitochondria
• MAPK kinases
• NFkappaB
• TNFalpha
• IL6
• Caspases
• Antioxidant
• Postconditioning

Links

Series:

• Mitochondrial Biogenesis

Categories:

• Cell Biology
• Clinical Practice

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on January 31, 2018

Financial Disclosures

• Dr. Zhi-Qing Zhao has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.