Neuropathology of neurodegenerative disorders
33 min
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- Introduction
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63 min
1. Drosophila genetics - the first 25 years- Prof. Dan Lindsley
- Establishment of the Primary Body Axes
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28 min
2. Homeotic genes in Drosophila's bithorax complex - The legacy of Ed Lewis- Prof. Francois Karch
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30 min
- Cell Type Specification and Organ Systems
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63 min
4. From germ cell specification to gonad formation- Prof. Ruth Lehmann
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46 min
5. Legacy of drosophila genetics: female germline stem cells- Prof. Michael Buszczak
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34 min
6. Intestinal stem cell-mediated repair in Drosophila 1- Prof. Tony Ip
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30 min
7. Intestinal stem cell-mediated repair in Drosophila 2- Prof. Tony Ip
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43 min
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34 min
9. Axon guidance in Drosophila- Prof. John Thomas
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35 min
10. Development and physiology of the heart- Prof. Rolf Bodmer
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37 min
11. Identification of host defenses in the Drosophila gut using genome-scale RNAi- Prof. Dominique Ferrandon
- Genome Organization and Function
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53 min
12. The genetic analysis of meiosis in Drosophila melanogaster females- Prof. R. Scott Hawley
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46 min
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36 min
14. Dorsal-ventral patterning of the Drosophila embryo- Prof. Mike Levine
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34 min
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27 min
16. Genome-wide pooled CRISPR screen in arthropod cells- Prof. Norbert Perrimon
- Behavior
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40 min
17. The development of the peripheral nervous system in the fruitfly Drosophila- Prof. Hugo J. Bellen
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46 min
18. TRP channels and opsins: universal mediators of sensory biology and behavior- Prof. Craig Montell
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72 min
19. Cracking the case of circadian rhythms by Drosophila genetics- Prof. Jeffrey C. Hall
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46 min
20. Sleep in Drosophila- Dr. Ralph Greenspan
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91 min
- Mechanism of Human Disease
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56 min
22. Human neurodegenerative disease: insights from Drosophila genetics- Prof. Nancy Bonini
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51 min
23. Rac-enhanced CAR immunotherapy: RaceCAR- Prof. Denise Montell
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34 min
- Evolution of Adaptive Novelties
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56 min
25. The evolution of morphological novelty- Prof. Nipam Patel
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36 min
26. The genetic architecture of complex traits: lessons from Drosophila- Prof. Trudy Mackay
- Archived Lectures *These may not cover the latest advances in the field
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25 min
27. Using gene expression information to provide insights into patterning and differentiation- Prof. Angelike Stathopoulos
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49 min
28. Regulation of gastrulation in Drosophila- Prof. Dr. Maria Leptin
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31 min
29. microRNA function in stem cells- Prof. Hannele Ruohola-Baker
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37 min
30. Drosophila stem cells- Prof. Michael Buszczak
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54 min
31. Genetics of chemosensory transduction: taste and smell- Dr. Leslie Vosshall
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34 min
32. Drosophila as a model for drug addiction- Prof. Ulrike Heberlein
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65 min
33. Cross-genomic analysis of human disease genes- Prof. Ethan Bier
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21 min
34. Metastasis of Drosophila tumors- Prof. Allen Shearn
Printable Handouts
Navigable Slide Index
- Introduction
- Amount of sleep is characteristic of each species
- Do all animals sleep?
- Cuckoo bees stay anchored to a twig
- Scorpions rest their head and claws on the ground
- Crayfish lean to one side
- Octopodes close their eyes
- Quiescent period of box jellyfish
- Paramecia are quiescent at night
- Fruit flies are quiescent at night
- Are these quiescent periods true sleep?
- Behavioral criteria for sleep
- Drosophila activity monitor
- Ultrasound movement detector
- Arousal threshold
- Sleep rebound
- Aging and sleep: humans
- Aging and sleep: flies (1)
- Aging and sleep: flies (2)
- Cumulative sleep loss with caffeine
- Effect of anti-histamines on sleep
- Gene activity in sleep vs. waking
- Sleep-regulated gene expression
- Physiology of sleep in Drosophila
- Local field potentials in sleep vs. waking
- Nature of physiological activity in sleep vs. waking
- Response to visual stimulus in sleep vs. waking
- Sleep stages in mammals
- Rapid eye movement (REM) sleep
- Cycling of sleep stages through the night
- Sleep recordings
- A separate stage of sleep in Drosophila
- Circadian rhythms and sleep
- Sleep rebound in arrhythmic per0 mutant
- Mortality in a rhythm mutant after sleep deprivation
- Induction of stress genes can reduce mortality
- Mortality of cys/hsp90 double mutant
- Hsp90 is a “chaperone” protein
- Response of neural mutants to sleep deprivation
- Neuromodulators and sleep
- Dopamine depletion increases fly sleep
- Effect of metamphetamine on dopamine and sleep
- Dopamine transporter mutant fumin
- Expression of arylalkylamine N-acetyltransferase
- Reactions catalyzed by AaNAT
- Rebound in AaNAT mutant
- cAMP mutants and sleep
- PKA, mushroom bodies and sleep
- Mushroom bodies and sleep
- 5HT1A receptor in mushroom bodies affects sleep
- Hypothalamus and SCN also regulate sleep
- Key elements in the EGF pathway (Drosophila)
- Secreted Egf-r ligand increases sleep
- Loss of Egf-r signaling decreases sleep
- Increase in sleep correlates with ERK activation
- Distribution of active ERK in brain after heat shock
- Expression of endogenous rho RNA and protein
- ERK and pars intercerebralis expression pattern
- Pars intercerebralis and hypothalamus
- Hyperexcitability (Shaker mutant) and sleep
- What is sleep for?
- Metabolic replenishment
- Synaptic homoeostasis
- The glycogen theory of sleep
- Examination of the glycogen theory in rats
- Glycogen decreases during waking and deprivation
- Glycogen levels differ among three mice strains
- Changes in levels of protein synthesis genes
- Closing remarks
- Literature cited
Topics Covered
- Evolution of sleep
- Sleep-like behavior in Drosophila
- Physiological and pharmacological characteristics
- Genetics of sleep: neurotransmitter and signal transduction systems
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Talk Citation
Greenspan, R. (2018, June 1). Sleep in Drosophila [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 31, 2025, from https://doi.org/10.69645/FIAQ2068.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Ralph Greenspan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
