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Printable Handouts
Navigable Slide Index
- Introduction
- Stem cells undergo asymmetric self-renewing
- Why stem cells are important
- Stem cells in Drosophila
- Cell types in the Drosophila ovary
- Markers expressed in specific cell types
- Lineage tracing (1)
- Lineage tracing (2)
- Lineage tracing (3)
- Stem cell niche
- Expanded niche expand stem cell population
- The GAL4/UAS system of gene expression
- Overexpression of dpp expands GSC population
- Dpp pathway in Drosophila
- GSC loss in dpp pathway mutants
- Clonal analysis in Drosophila
- Downstream components of dpp pathway
- Model for Dpp regulation of GSCs
- Lost GSCs are replaced
- Cell types in the Drosophila testis
- upd is expressed in Hub
- Jak/Stat pathway in Drosophila
- Disruption of Jak/Stat results in GSC loss
- Over-expression of upd
- Model of testis niche
- Niche maintains GSC
- Can cysts revert back to stem cells? (1)
- Can cysts revert back to stem cells? (2)
- Stat mutant cells exhibit precocious development
- Differentiated cysts breakdown and repopulation
- Niches maintain GSCs and drive dedifferentiation
- Do stem cells signal back to niche?
- Notch Delta signaling pathway
- Activation of Notch pathways
- Loss of Notch signaling leads to loss of GSCs
- Drosophila digestive tract
- Clonal analysis
- Midgut has multipotent stem cells
- Notch signaling drives differentiation in midgut
- Silencing of differentiation factors in stem cells
- Expression of nuclear proteins in stem cells
- scny shares homology with yeast and USPs
- scny mutant cells display elevated H3mK4 levels
- scny mutants exhibit chromatin changes
- scny mutants exhibit stem cell loss in ovary (1)
- scny mutants exhibit stem cell loss in ovary (2)
- scny functions in follicle stem cells
- Cell lineage in the Drosophila adult midgut
- DAPT blocks Notch activity in midgut
- DAPT suppresses stem cell loss in scny midguts
- Model for SCNY function in stem cells
- Take home messages
- Acknowledgments
- References for specific images
Topics Covered
- Lineage tracing
- Stem cell niches
- Germline stem cell niche in ovary
- Germline stem cell niche in testis
- Dedifferentiation
- Stem cell signaling back to the niche
- Intestinal stem cells
- Stem cell chromatin
Talk Citation
Buszczak, M. (2008, September 29). Drosophila stem cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 14, 2024, from https://doi.org/10.69645/DFLN2727.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Michael Buszczak has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.