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Printable Handouts
Navigable Slide Index
- Introduction
- Protein sorting in the eukaryotic cell
- Intracellular transport of proteins
- Intracellular distribution of radioautographic grains
- The endoplasmic reticulum
- Newly synthesized proteins sequestered in ER
- Precursor/processed forms of secretory proteins
- A mechanism for protein translocation
- The signal hypothesis: Gunter Blobel
- Topogenic signal directs protein translocation
- Signal sequence structure
- How is the signal sequence recognized?
- Ribosome/ nascent chain/ SRP complexes
- SRP/SRP receptor-directed targeting of ribosomes
- Schematic overview of protein translocation
- Mechanism of protein translocation in the ER
- Sec61p: the ER protein conducting channel
- The "translocon" composition
- Sampling of the ER membrane bilayer
- Protein conducting channel identification in the ER
- Membrane proteins integration model: part I
- Membrane proteins integration model: part II
- Translational regulation on the ER
- mRNA translation rates are governed by PERK
- mRNA segregation in the cell
- Summary
Topics Covered
- Protein sorting in the eukaryotic cell
- The discovery of the secretory pathway
- Overview discussion of the structure/function of the endoplasmic reticulum
- Experimental protocols and landmark experiments leading to the discovery of protein translocation
- The signal hypothesis
- Signal sequence structure
- Signal sequence recognition
- SRP receptor and targeting to the ER
- Mechanism of protein translocation and the protein translocation channel
- Translational regulation on the ER
- The unfolded protein response
- mRNA partitioning in the cell
- Are there alternative pathways for compartmentalizing protein synthesis?
Talk Citation
Nicchitta, C. (2007, October 1). Endoplasmic reticulum, protein synthesis and translocation machinery [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 6, 2024, from https://doi.org/10.69645/PHPW8297.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Christopher Nicchitta has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.