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In vivo drug screening

Published on October 30, 2025   5 min

A selection of talks on Pharmaceutical Sciences

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0:00
My name is Dr. Wayne Carter. This lecture is entitled In Vivo Drug Screening. Animal Models.
0:09
Drug properties need to be tested in vivo. This utilises animals, typically mammals, as a model of human physiology and/or the human disease for which the drug will be applied.
0:24
Production of Animal Models. Animal models are generated using a number of mechanisms, including breeding of animals with natural mutations. For example, if the natural mutation in the animal matches the one in the human condition, then those animals are bred as a representation of the disease. Generation of animals with specific genetic modifications is possible. For example, knocking out a specific gene. The application of drug or a toxin to induce a disease.
0:57
CRISPR Gene Editing Models. Recent development in Nobel Prize-winning CRISPR technology, which stands for clustered regularly interspaced short palindromic repeats, provides a means of generation of an animal model with individual gene-editing possibilities.
1:16
Disease Models. There are a range of established models for diseases, including those of the central nervous system (CNS), such as the chemical induction MPTP model of Parkinson's disease. MPTP stands for 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine, and it is typically injected into mice or rats, where it gets modified and taken up specifically into dopaminergic neurons within the substantia nigra pars compacta, and therefore models Parkinson's disease in humans.

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