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- Architecture of the ribosome RNA-protein machine assembly
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2. Assembly of the 30S ribosomal subunit in vitro and in cells
- Prof. James Williamson
- Decoding and peptide bond formation
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3. How aminoacyl-tRNA synthetases translate the genetic code
- Dr. Stephen Cusack
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5. Elongation of protein synthesis: structural basis of the process of decoding
- Prof. Marina Rodnina
- Initiation of protein synthesis
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7. Factor independent initiation of protein synthesis by IRES RNAs
- Prof. Jeffrey Kieft
- Elongation and termination of protein synthesis
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8. Translocation: movement of tRNA and mRNA through the ribosome
- Prof. Harry Noller
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9. Recoding: getting more out of the message by shifting reading frame and redefining codon meaning
- Prof. John Atkins
- Prof. Raymond Gesteland
- Co-translational protein secretion
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10. Mechanism of translocon function: current insights and models
- Prof. Arnold Driessen
- How antibiotics target the ribosome
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12. Antibiotic inhibition of ribosome function
- Dr. Daniel Wilson
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13. Structure-based drug design targeting infectious disease
- Dr. Erin Duffy
- Archived Lectures *These may not cover the latest advances in the field
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15. Introduction to the ribosome
- Prof. Anders Liljas
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16. The structure of the intact ribosome and ribosomal subunit interactions
- Dr. Jamie H. Doudna Cate
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17. Structural insights into decoding of mRNA by the ribosome
- Prof. Venki Ramakrishnan
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18. Chemistry of peptide bond formation
- Prof. Rachel Green
Printable Handouts
Navigable Slide Index
- Introduction
- How is a polypeptide synthesized? (1)
- How is a polypeptide synthesized? (2)
- 1940
- DNA
- The genetic code
- tRNA (1)
- Crick's adaptor hypothesis, 1956
- sRNA - tRNA
- tRNA (2)
- tRNA: the substrate of translation
- The charging system - 20 tRNA synthetases
- RNA and ribosomes (1)
- Ribosomes seen as black dots by EM
- RNA and ribosomes (2)
- 2D gel of the ribosomal proteins from E. coli
- Composition of ribosomes
- Relationship between ribosomal proteins
- 1964 - function is structure
- Electron microscopy of ribosomes
- Localization of ribosomal proteins
- Some ribosomal proteins have unusual structure
- 1978 - E. coli rRNA
- tRNA sites
- 2000 - crystal structures of ribosomes
- Ribosomal sites (1)
- Phases of translation
- Bacterial translation factors
- Ribosomal sites (2)
- EF-Tu
- The GTP binding consensus elements of EF-G
- The EF-Tu cycle
- Interactions with the ternary complex seen on EM
- Dissociation of EF-Tu
- Is the ribosome a ribozyme?
- EF-G translocates pp-tRNA from A- to P-site
- EF-G bound to the ribosome
- When and how does L12 interact?
- L12 3-D structure
- L7/L12 dimer by NMR
- L12 seen by NMR in 70S ribosomes
- The elongating ribosome binding of aa-tRNA
- Translocation by EF-G
- EF-G interaction surface on L12
- RF2 has almost the shape of a tRNA
- Conformational changes seen from 3-D structures
- Ribosome recycling RRF mimics tRNA
- Neither RF2 nor RRF bind as tRNA
Topics Covered
- The understanding of heredity and translation of proteins based on the genetic information
- Intensive structural studies of ribosomes, tRNAs and translation factors
- A historical overview
- Main components of translation
Talk Citation
Liljas, A. (2008, May 15). Introduction to the ribosome [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 21, 2025, from https://doi.org/10.69645/YXJZ2865.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Anders Liljas has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.