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Navigable Slide Index
- Introduction
- E. faecalis can adapt to many different situations
- Adaptation can be short-term or longer term
- Sex-pheromone plasmids and conjugation
- A genetic map of the pCF10 plasmid
- Main points of the talk
- Original 1-way signaling model is overly simple
- Pheromone synthesis and control circuits (1)
- Pheromone synthesis
- The PrgY/TraB family tree
- Model for PrgY function
- Part I -summary: action from the membrane out
- Early regulatory events in pheromone induction
- PrgX function in PrgQ transcription control
- Structure of PrgX/cCF10 vs. PrgX
- Structure of PrgX/iCF10 - C-terminus
- Integration of structures into working models
- The remaining issues with the looping model
- Main points
- Plasmid pCF10
- In vivo plasmid transfer
- Induction of pCF10 transfer by plasma
- Pheromone synthesis and control circuits (2)
- PrgB expression increases virulence
- Evolution and "kluging"
- Conclusion
- Acknowledgements
- References (1)
- References (2)
Topics Covered
- Overview of the evolutionary and medical significance of plasmids in E faecalis
- Overview of cell-cell signaling and plasmid transfer
- The sex pheromone system
- Pheromone production and control plasmid pCF10 as a model for pheromone-controlled plasmid transfer
- Mechanism of pheromone induction
- Multiple roles for pheromone induction
- Maintenance of complexity in evolution
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Talk Citation
Dunny, G. (2008, January 28). The pCF10-encoded pheromone response: cell-cell signaling, complexity and evolution [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 9, 2024, from https://doi.org/10.69645/LEXM1474.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Gary Dunny has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
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