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Navigable Slide Index

1. Intro slide
2. Genome of eukaryotes
3. Crystal structure of a nucleosome core particle
4. Modifications of histones
5. Epigenetics
6. Biology of histone acetylation
7. Acetylation: Structural changes
8. Acetylation: Binding surface
9. Histone lysine methylation
10. Multiple HATs and HDACs in yeast
11. Overlapping functions of HATs and HDACs
12. Information in histone modification patterns
13. Histone info in yeast
14. Histone info in human cells
15. ChIP on chip
16. Representation of acetylation data
17. Average acetylation levels for ORF clusters
18. Biological significance of acetylation clusters
19. Expression levels of acetylation clusters
20. Functional enrichment of acetylation clusters
21. Identification of DNA motifs in acetylation clusters
22. Enrichment of acetylation clusters for transcription
23. Information storage in histone modifications
24. Information storage in human cancer
25. Protocol flowchart
26. Detection of histone modifications in cancer
27. Distribution of staining across all samples
28. Epigenetic clustering of cancer patients
29. Epigenetic information and clinical outcome
30. Best simple rule
31. Validation of simple rule
32. Epigenetic information as prognostic marker
33. Conclusions

Topics Covered

• Types and functions of histone modifications
• Histone code hypothesis
• Epigenetics and transcription regulation
• Relevance for human disease

Links

Series:

• Eukaryotic Gene Regulation

Categories:

• Cancer
• Cell Biology
• Genetics & Epigenetics

Therapeutic Areas:

• Oncology

Talk Citation

Kurdistani, S. (2007, October 1). Epigenetic information in gene expression and cancer [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 22, 2024, from https://doi.org/10.69645/ULRL7815.
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Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Siavash Kurdistani has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.