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1. Introduction
2. G6PD - a "housekeeping" enzyme
3. G6PD gene structure (1)
4. G6PD and X-inactivation
5. G6PD gene structure (2)
6. G6PD promoter
7. G6PD protein
8. G6PD protein and NADP binding
9. G6PD enzymology
10. G6PD - pentose synthesis vs. oxidant stress
11. G6PD - oxidant stress and apoptosis
12. Regulations of G6PD expression and activity
13. Tissue specific G6PD expression
14. G6PD deficiency (1)
15. G6PD and positive selection by malaria
16. Common variants
17. Worldwide distribution of G6PD deficiency
18. G6PD gene mutations
19. WHO biochemical classification
20. Methods to identify G6PD deficiency
21. G6PD deficiency (2)
22. G6PD deficiency and hemolysis (1)
23. G6PD deficiency and hemolysis (2)
24. Treatment options
25. G6PD, other cell types and disease states
26. Role of G6PD in neutrophil function (1)
27. Role of G6PD in neutrophil function (2)
28. Role of G6PD in neutrophil function (3)
29. G6PD and sepsis after severe injury
30. G6PD deficiency and risk of diabetes
31. Diabetes and acquired G6PD deficiency
32. Hyperglycemia decreases G6PD activity (1)
33. Hyperglycemia decreases G6PD activity (2)
34. G6PD and hypertension
35. G6PD and gestational hypertension
36. G6PD as an antioxidant in non-erythrocytic cells
37. G6PD and vascular endothelial cells (EC)
38. G6PD and vescular EC oxidant stress
39. G6PD-deficient EC and vascular oxidant stress
40. G6PD-deficient EC and nitric-oxide (1)
41. G6PD-deficient EC and nitric-oxide (2)
42. G6PD deficiency and EC migration
43. G6PD deficiency and tube formation
44. In vivo matrigel assay
45. G6PD deficiency and vascular reactivity (1)
46. Brachial artery vascular reactivity
47. G6PD deficiency and vascular reactivity (2)
48. G6PD and cytosolic redox states in myocytes
49. G6PD and ischemia - reperfusion
50. Summary

Topics Covered

• G6PD and X-chromosome
• Genetics
• Protein structure and function
• G6PD and neutrophil function/inflammation
• Role of G6PD in diabetes mellitus
• Hypertension
• G6PD modulates vascular oxidant stress
• Angiogenesis is regulated by G6PD activity
• G6PD and vascular reactivity
• G6PD, cardiomyocytes and ischemia-reperfusion

Links

Series:

• Protein Epidemiology

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Dr. Jane Leopold has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.