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Navigable Slide Index

1. Introduction
2. Overview - a brief history
3. Short RNAs are key players of gene regulation
4. Overview - the phenomenon of RNAi
5. The discovery of RNAi in C.elegans
6. RNAi in C.elegans is systemic
7. RNAi in other organisms
8. Delivery of RNAi (dsRNA)
9. Overview - a genetic pathway for RNAi
10. A genetic screen for RNAi pathway identification
11. Genes required for RNAi
12. RNAi, transposon silencing and co-suppression
13. RNAi, transposon silencing, co-suppression genes
14. Identification of new RNAi genes
15. Identification of new RNAi genes - biochemistry
16. Systemic RNAi: the genetics of spreading
17. RNAi spreading - C.elegans experiments
18. Genes of RNAi spreading
19. Overview - RNAs and endogenous RNAi
20. A short history of microRNAs
21. Biogenesis of microRNAs
22. Links between microRNA biogenesis and RNAi
23. Clustering of mIR-35 family genes
24. MicroRNA families in C. elegans
25. The conserved let-7 family
26. Cell divisions in C.elegans development
27. lin-4(lf) mutants change cell divisions of the L1
28. Heterochronic phenotypes: precocious or retarded
29. MicroRNAs that control developmental switches
30. let-7 family members control developmental timing
31. Control of early and late developmental switch
32. Emerging roles for microRNA
33. Other small RNAs
34. Overview - RNAi screening
35. Whole genome RNAi screens - methods
36. Whole genome screens: advantages and problems
37. Whole genome screens: abnormal phenotypes
38. Overview - biology of RNAi in C. elegans
39. Biological roles for RNAi
40. RNAi as the guardian of the genome
41. References (1)
42. References (2)

Topics Covered

• Small non-coding RNA pathways
• Genetics of RNAi
• MicroRNAs
• RNAi screening
• Biological roles of RNAi
• Systemic RNAi in C. elegans

Links

Series:

• RNA Interference

Categories:

• Cell Biology
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007
• Reviewed on September 10, 2020

Financial Disclosures

• Dr. Eric Miska has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.