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Navigable Slide Index

1. Introduction
2. Composition of the eubacterial ribosome
3. Principle of translation
4. Elongation of the polypeptide chain
5. Role of elongation factors EF-G and EF-Tu
6. The four phases of translation
7. Initiation - sequence of events
8. Visualization of ribozome and translation process
9. Cryo-electron microscopy of single molecules
10. Transfer RNA - tRNA
11. Lock and key fit
12. The 70S ribosome
13. mRNA , tRNA and polypeptide interactions
14. The path of tRNA
15. The path of mRNA
16. Elongation factors and molecular mimicry
17. Implications of structural mimicry
18. Elongation cycle
19. Elongation cycle of protein biosynthesis
20. Highly conserved features in ribosomes
21. Tree diagram - philogeny of ribosomal RNA

Topics Covered

• Composition of the ribosome
• Principle of translation
• The four phases of translation
• Structure and function of small and large ribosomal subunits
• Role of elongation factors
• The paths of messenger RNA, transfer RNA and the nascent polypeptide
• Elongation cycle and binding positions of elongation factors
• Decoding, peptidyl transfer and translocation
• Phylogenetic conservation of ribosomal architecture

Links

Series:

• From DNA to Proteins

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Joachim Frank has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.