• Special Designs
• 46 min
  1. Family-based association tests: introduction

  • Dr. Christoph Lange
• 29 min
  2. Family-based association tests: FBAT testing strategies for large-scale association studies

  • Dr. Christoph Lange
• 37 min
  3. Two-stage genome-wide association designs

  • Dr. Andrew Skol
• Special Populations
• 40 min
  4. Admixture mapping

  • Dr. Paul McKeigue
• Whole-Genome Studies: Types of Data
• 34 min
  5. QTL association mapping

  • Prof. Bruce Weir
• 50 min
  6. Adjusting for population structure in genetic association studies

  • Prof. David Balding
• Whole-Genome Studies 2: Methods
• 47 min
  7. Whole-genome association studies: practical advice and considerations

  • Dr. Mike Weale
• Archived Lectures *These may not cover the latest advances in the field
• 49 min
  8. Family-based association tests: FBATs for various data types

  • Dr. Christoph Lange
• 44 min
  9. Choosing between family-based and population-based association designs

  • Dr. Ren-Hua Chung
• 54 min
  10. Use of isolated populations: pitfalls and potential

  • Dr. Leena Peltonen
• 40 min
  11. Information on untyped variation in genome-wide association studies

  • Dr. Dan Nicolae
• 37 min
  12. Detecting multiple associations in genome-wide studies

  • Prof. Frank Dudbridge
• 30 min
  13. Genome scanning by composite likelihood

  • Dr. Andrew Collins
• 41 min
  14. Multistage sampling for genetic studies

  • Prof. Robert Elston
• 39 min
  15. Screening large-scale association study data: exploiting multi-gene interactions with random forests

  • Dr. Kathryn Lunetta
• 43 min
  16. A survey of multi-locus methods for analysis of large SNP datasets

  • Mr. A. Geert Heidema
• 34 min
  17. Sequential analysis methods in genomic scans

  • Prof. Michael Province

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. FBATs for multivariate data
3. Example: CAMP study
4. CAMP study: applying FBAT approach (1)
5. CAMP study: applying FBAT approach (2)
6. Why multivariate test?
7. FBAT-GEE
8. Interpretation of FBAT-GEE test results
9. CAMP study: groups of phenotypes
10. CAMP study: applying the FBAT-GEE approach
11. FBAT-GEE for the atopy group phenotypes
12. Summary of FBAT-GEE
13. FBATs for time-to-onset data
14. Time-to-onset data for complex diseases
15. Time-to-onset data: working hypothesis
16. Deriving a test statistic: notation
17. FBAT-logrank and Wilcoxon (1)
18. FBAT-logrank and Wilcoxon (2)
19. FBAT-logrank and Wilcoxon: application
20. Kaplan-Meier plots for allele 4 in APOE
21. FBAT-logrank and Wilcoxon test results
22. Summary: FBAT-logrank and FBAT-Wilcoxon
23. FBAT for longitudinal data
24. Quantitative trait analysis
25. Quantitative traits for complex diseases
26. Longitudinal traits/correlated data
27. Longitudinal data in family studies
28. Longitudinal data in family studies: FBAT-PC
29. FBAT-PC: notation
30. The variables of FBAT-PC test
31. FBAT-PC: the alternative hypothesis
32. Solution of the maximization problem (1)
33. Solution of the maximization problem (2)
34. Properties of the overall FBAT-PC phenotypes
35. Estimation of VG and VP
36. The heritability of the FBAT-PC phenotype (1)
37. The heritability of the FBAT-PC phenotype (2)
38. Heritability of overall phenotype: 1st scenario
39. Heritability of overall phenotype: 2nd scenario
40. Heritability of overall phenotype: 3rd scenario
41. Summary: heritability of the FBAT-PC phenotype
42. CAMP study: applying FBAT-PC approach
43. CAMP: univariate data analysis (SNP1 in IL10)
44. CAMP: FBAT-PC analysis
45. Summary of FBAT-PC (1)
46. Summary of FBAT-PC (2)
47. Multi-marker FBATs

Topics Covered

• Childhood asthma management program (CAMP)
• Multivariate tests
• FBAT-GEE
• FBATs for time-to-onset data
• Time-to-onset data for complex diseases
• FBAT logrank and Wilcoxon
• Quantitative trait analysis
• Quantitative traits for complex diseases
• Longitudinal data
• FBAT-PC
• Estimation of VG and VP
• The heritability of the FBAT-PC phenotype
• Heritability of the overall phenotype
• CAMP: univariate data analysis
• CAMP: FBAT-PC analysis
• Multi-marker FBATs

Links

Series:

• Genetic Epidemiology II

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Dr. Christoph Lange has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.