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Navigable Slide Index

1. Introduction
2. Discovery of therapeutic antibodies
3. Discovery of monoclonal antibodies
4. Rat Campath-1: a therapeutic antibody
5. IgG structure and genes
6. IgG antibody
7. Mouse-human chimaeric antibodies
8. Antibody variable regions
9. Humanized antibodies
10. Packing of CDRs and FRs
11. Auto-correction with antigen?
12. Campath-1H: treatment of NHL
13. Campath
14. Number of mAbs entering clinical studies by year
15. Immunogenicity of engineered antibodies
16. Avastin and Herceptin
17. FDA-approved therapeutic antibodies
18. Human antibodies
19. The immune strategy
20. Generation of diversity: VH repertoires
21. Combinatorial VH x VL repertoires
22. Phage display of antibody scFv fragment
23. Selecting antibodies by phage display
24. Imaging with anti-EDB
25. Humanising by guided selection
26. Humira
27. Other human antibodies
28. Antibody single domain
29. Aggregation of proteins
30. Human\camel single domains
31. Heat-cool selection of VH by protein A
32. Properties of dAbs from CDR-only repertoire
33. Heat-cool selection by infectivity
34. Single antibody domains: a versatile platform

Topics Covered

• Therapeutic antibodies
• Monoclonal antibodies
• Rat Campath-1
• IgG structure and genes
• IgG antibody
• Mouse-human chimeric antibodies
• Humanized antibodies
• Campath-1H
• B-cell chronic lymphocytic leukemia (B-CLL)
• Multiple sclerosis
• Immunogenicity of engineered antibodies
• Avastin and Herceptin
• The immune strategy
• Generation of diversity
• Humira
• Human therapeutic antibodies

Links

Series:

• Monoclonal Antibodies as Therapeutic Agents

Categories:

• Immunology
• Methods

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Sir Gregory Winter has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.