Skip to main content
Search

Clinical pharmacology during pregnancy and lactation

Published on August 29, 2024   36 min

A selection of talks on Pharmaceutical Sciences

Please wait while the transcript is being prepared...
0:00
Welcome to this lecture on clinical pharmacology during pregnancy and lactation. I'm Karel Allegaert. I'm a clinician-researcher working at Rotterdam University as well as KU Leuven.
0:14
The overarching learning objective of this lecture is to highlight the specific characteristics related to both pharmacokinetics and pharmacodynamics and related to these pharmacodynamics also aspects related to safety for mother, fetus and potentially lactating infant. As we all know, a given dose will result in a given concentration in a compartment in the body; most commonly studied is obviously the blood compartment. This concentration will subsequently result in a given effect and that's what makes a difference between pharmacokinetics and pharmacodynamics. Obviously, pregnancy in itself will have a major impact on drug handling and potentially also on drug effects. This is the focus or the learning objective of this lecture.
1:01
As I already somewhat alluded to there is extensive variability. This means that the pharmacokinetics and/or pharmacodynamics may change significantly throughout pregnancy. An important message hereby is that pregnancy in itself is not a dichotomous covariant. As for instance, consecutive trimesters of pregnancy may have different impacts on drug handling or drug effects. To somewhat further extent, the idea initially raised on children and their specific characteristics to study drugs. The child is not just a small adult and the newborn is not just a small child along the same way pregnant woman is not just a woman with a big belly.

Quiz available with full talk access. Request Free Trial or Login.

Show
Hide

Clinical pharmacology during pregnancy and lactation

Embed in course/own notes