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Printable Handouts
Navigable Slide Index
- Introduction
- Understanding lipoprotein metabolism
- Lipids are water-insoluble
- Polar and apolar molecules
- Structure of Low-Density Lipoproteins (LDL)
- Separation of lipoproteins
- Lipoprotein classes
- Composition of plasma lipoproteins
- Key functions of classical apolipoproteins
- Clinical measures of lipoproteins
- Lipoprotein(a)
- Lipoproteins are lipid transporters
- Lipid transport in blood
- ApoB containing lipoproteins in fasting and non-fasting conditions
- Dietary lipid transportation
- Postprandial triglyceride-metabolism
- Chylomicronemia syndrome (type I hyperlipoproteinemia)
- Postprandial triglyceride-metabolism: regulation
- Metabolism of triglyceride-rich lipoproteins
- Fasting triglyceride and VLDL/LDL metabolism
- Synthesis, function and recycling of the LDL-receptor
- PSCK9 diminishes the abundance of LDL-receptors
- Familial hypercholesterolemia
- Regulation of cellular lipid-homeostasis by the LDL-receptor
- Regulation of target genes in response to low cellular cholesterol
- Regulation of target genes in response to high cellular cholesterol
- Catabolism of LDL
- LDL-cholesterol lowering therapies
- Important determinants of plasma levels of lipids in atherogenic lipoproteins
- The lifecycle of LDL and HDL
- HDL metabolism: biogenesis
- Lecithin-cholesterol acyltransferase
- HDL metabolism: maturation
- Role of CETP in generating a proatherogenic lipoprotein profile
- HDL metabolism: catabolism
- Biliary lipid excretion
- Regulation of ABCA1 gene-expression by oxysterols and retinols
- Reverse cholesterol transport
- Negative feedback and positive feedforward responses to cholesterol
- Pleiotropic functions of HDL
- Structure-function relationship of HDL
- Lipoprotein traits as risk factors or markers of atherosclerotic vessel disease
- Acknowledgements
Topics Covered
- Role of plasma lipoproteins
- Structure of lipoproteins
- Apolipoproteins
- Transportation of triglycerides, chylomicrons and very low-density lipoproteins (VLDL)
- Low-density lipoproteins (LDL)
- High-density lipoproteins (HDL)
- Cholesterol homeostasis
- Hypercholesterolemia
- Drugs that lower plasma levels of cholesterol by promoting the hepatic removal of LDL
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Talk Citation
von Eckardstein, A. (2024, July 31). Lipoproteins [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 16, 2024, from https://doi.org/10.69645/QGAA7112.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Arnold von Eckardstein has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Physiology & Anatomy
Transcript
Please wait while the transcript is being prepared...
0:00
I'd like to introduce myself.
I'm Arnold von Eckardstein,
and I have been invited
to give an overview
about lipoproteins
and my normal task is
to work at the University
Hospital of Zurich
and I'm a specialist in
laboratory medicine.
So I will also touch a bit
about the analysis
of lipoproteins in
the laboratory and my
research specialty
is lipoproteins and
atherosclerosis.
That's probably the
reason why I've been
asked to give this presentation.
0:33
The next slide shows
you the rationale
why I think it is important for
medical students or students
in biomedical sciences
to understand the
structure, function
and metabolism of lipoproteins.
The most important medical
reason is that lipoproteins,
especially APoB containing
lipoproteins like LDL,
are an important causal risk
factor in atherosclerosis.
You see here already the
arguments that I will bring
forward at the end of
my presentation again.
We know that high
LDL-cholesterol levels
increase the risk of
myocardial infarction.
We know from genetic studies
that genetic reasons of
high LDL-cholesterol also
increase the risk of
myocardial infarction,
and people who have genetically
determined low levels of
LDL-cholesterol have a low
level risk of atherosclerosis.
If we go for trials,
all drugs that lower
LDL-cholesterol or also
dietary interventions
that lower LDL-cholesterol
are shown to
reduce the risk of
myocardial infarction.
Finally, in animal experiments,
if you want to model
atherosclerosis,
it's not possible
to do this without
inducing hypercholesterolemia
in these animals.
It's very clear
LDL-cholesterol and
also other lipoproteins
are causal risk factors of
atherosclerosis and they are
treatable risk factors and
it's important to understand
the rationale behind that.