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- Part I. General subjects
-
1. Need for drug delivery systems 1
- Prof. Ana Catarina Silva
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2. Need for drug delivery systems 2
- Prof. João Nuno Moreira
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3. Routes of drug delivery
- Prof. Dr. Sven Stegemann
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4. Transporters in drug delivery
- Dr. Pravin Shende
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5. The theory and applications of controlled release principles
- Dr. Michael J. Rathbone
- Part II. Routes for drug delivery
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6. Oral drug delivery
- Dr. Vineet Kumar Rai
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7. Transdermal drug delivery
- Prof. Sabine Szunerits
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8. Pulmonary drug delivery
- Prof. Anthony J. Hickey
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9. Gastrointestinal drug delivery
- Prof. Susan Hua
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10. Mucoadhesive drug delivery systems
- Dr. Panoraia I. Siafaka
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11. Ocular drug delivery
- Prof. Emily Dosmar
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12. Vaginal and uterine drug delivery
- Prof. José Luis Arias Mediano
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13. Drug-eluting implants
- Dr. Aliasger K. Salem
- Part III. Materials for drug delivery
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14. Polymers as nanocarriers for controlled drug delivery
- Prof. Dr. Marcelo Calderón
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15. Polymeric gels for drug delivery
- Dr. G. Roshan Deen
- Ms. Dora Safar
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16. Liposomes as a drug delivery system
- Dr. G. Roshan Deen
- Ms. Bushra Hasan
- Ms. Renad AlAnsari
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17. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)
- Prof. Ana Catarina Silva
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18. Micellar drug delivery
- Prof. Francesco Cellesi
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19. Nanocrystals in drug delivery
- Prof. Eliana Souto
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20. Layer-by-layer assemblies for drug delivery
- Prof. Szczepan Zapotoczny
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21. Inorganic nanostructured interfaces for therapeutic delivery
- Prof. Tejal Desai
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22. Inorganic porous drug delivery carriers
- Prof. Jessica Rosenholm
- Part IV. Specifics of drug delivery
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23. Delivery of genes and nucleotides
- Prof. Esam Yahya
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24. Vaccine delivery
- Prof. Sevda Şenel
- Part V. Drug delivery in various diseases
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25. Drug delivery for cancer therapeutics
- Prof. Tejraj Aminabhavi
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26. Nanomedicines for brain diseases
- Prof. Giovanni Tosi
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27. Drug delivery to the colon
- Prof. Susan Hua
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28. Role of the lymphatic system in drug absorption
- Dr. Kishor M. Wasan
Printable Handouts
Navigable Slide Index
- Introduction
- Process in drug discovery techniques
- Challenges in formulation development
- Pharmaceutical R&D: nanoparticles in industry
- Classification of organic nanocarriers
- Absorption enhancing effect of SLN
- Effect of particle size: Noyes-Whitney equation
- Effect of particle curvature
- Effect of particle size: rutin nanocrystals
- Effect of particle size in different conditions
- Nanocrystals production approaches
- Production approaches: bottom-up
- Production approaches: top-down
- Production approaches: combined methods
- Dapsone nanocrystals – wet bead milling
- Wet bead milling: small scale vs. pilot scale
- SN-38 nanocrystals – ultrasound reprecipitation
- SN-38 nanocrystals – cytostatic activity
- Meloxicam nanocrystals – ball milling (1)
- Meloxicam nanocrystals – ball milling (2)
- Meloxicam nanocrystals – pharmacokinetics
- Meloxicam nanocrystals – in vivo analgesia (male vs. female)
- Meloxicam nanocrystals – in vivo analgesia
- Nanocrystals in vivo performance
- Itraconazole nanocrystals - pharmacokinetics
- Marketed nanocrystals by top-down (1)
- Marketed nanocrystals by top-down (2)
- Marketed nanocrystals by top-down (IV route)
- Thank you
Topics Covered
- Process in drug discovery techniques
- Challenges in formulation development
- Pharmaceutical R&D: nanoparticles in industry
- Classification of organic nanocarriers
- Nanocrystals production approaches
- Wet bead milling
- Ball milling
- Nanocrystals in vivo performance
Talk Citation
Souto, E. (2024, July 31). Nanocrystals in drug delivery [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 1, 2024, from https://doi.org/10.69645/NPOY7507.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Eliana Souto has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Pharmaceutical Sciences
Transcript
Please wait while the transcript is being prepared...
0:00
Hello. My name is Eliana Souto,
and I was offered to talk about
the topic of nanocrystals
in drug delivery.
0:10
I would like to start by saying
that the process we have
been witnessing in
techniques that
currently support
drug discovery,
as happens with genomics,
proteomics, and high-throughput
screening methods, among others,
is resulting in an exponential
increase in the number of
potential candidates to be used
as active pharmaceutical
ingredients.
In rigor, a new drug candidate,
undergoes a time-consuming
development process,
and we still face a
shortage of examples of
these potential drugs actually
reaching Phase 1
clinical studies.
Within this scenario,
formulation development
becomes instrumental to ensure
that a potential
drug candidate is
bioavailable and reaches
the site of action.
0:57
Besides that, as
a number of physical
and chemical properties
of drugs are becoming
even more diversified,
and improved, with smart
drug delivery systems
with functional properties
are being proposed.
Most of the problems encountered
in formulation development are
attributed to: the
low water solubility
of potential drug candidates;
the low in vitro and
in vivo stability;
the reduced bioavailability as
a result of the limited
absorption of the tract;
the risk of systemic
distribution
requiring targeted delivery;
difficulties in being approved
by the regulatory authorities,
and also the difficulties in
scaling up of the
production process.