We noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- The principal actors: research animals
- Minimising harm to research animals
- Replacement
- Refinement
- Why is welfare so important?
- Minimising harm
- Reduction
- Why apply the 3Rs?
- Which “R” takes precedence?
- Not just animal ethics
- 12Rs framework
- Animal welfare, 3Rs and beyond
- Scientific integrity Rs
- Why is welfare so important?
- PREPARE and ARRIVE (1)
- PREPARE and ARRIVE (2)
- Tackling the reproducibility, reliability and translatability epidemic
- Social value Rs: culture of care
- A “culture of care”
- Social value Rs
- Are the 12Rs applicable globally?
- The 3Rs and beyond
Topics Covered
- 3Rs of animal research
- Enabling high-quality humane research involving animals
- Research animals
- Minimising harm to research animals
- Replacement, refinement and reduction
- 12Rs framework
- Animal welfare Rs, ethical integrity, social value Rs and scientific integrity Rs
- PREPARE and ARRIVE guidelines
Links
Series:
Categories:
External Links
Talk Citation
Lewis, D. (2024, June 30). The 3Rs of animal research & beyond [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 7, 2024, from https://doi.org/10.69645/HWNN8984.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
Other Talks in the Series: Animal Models in Biomedical Research
Transcript
Please wait while the transcript is being prepared...
0:00
The 3Rs of Animal
Research and Beyond
Enabling High-Quality Humane
Research Involving Animals
My name is Dave Lewis.
I'm a professor of education for
professional and
sustainable development
in the School of Biomedical
Sciences University of Leeds
in the United Kingdom.
0:20
Think about animal research.
The principal actors are the
research animals themselves.
These go anything from
single-cell protozoa
to water fleas, flies,
in the United Kingdom, at
least, predominantly rats and
mice but also can
include farm animals,
fish or wild animals.
They're typically called
laboratory animals,
however, laboratory
is not only the
traditional bioscience
research laboratory
but could be a farm.
It could be a wildlife park.
It could be a zoo.
We use animals for many
research purposes which
include understanding human
and animal biology and
disease, to develop
new medicines, for
safety testing, for education
and training in
higher education.
The laws governing
animal research
across the world
vary considerably.
Many countries don't have
any laws governing animal
research specifically.
They might be in
other laws as well.
Similarly, ethical review
and ethics committees are
in their infancy or non-existent
in many parts of the world.
Animals cannot give
informed consent.
Therefore working
with research animals
is a privilege and not a right.
1:35
If we have to work
with research animals,
then we have to minimize
the harm to them.
This involves the principles of
humane experimental
technique introduced by
Russell and Burch in 1959
also known as the 3Rs.
So replacement as getting rid
of the use of animals in
research, refinement,
minimizing their pain, suffering
and distress and reduction,
reducing the number of
animals that we use.