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- Research interviews
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1. The regulation of cell therapy- Prof. Moutih Rafei
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17 min
2. How and why neurons die in Alzheimer's disease?- Prof. Bart De Strooper
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11 min
3. The future of blood tests in cancer treatment- Dr. Isaac Garcia-Murillas
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4. Role of marketing authorization holder in drug safety- Dr. Raphael Elmadjian Pareschi
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25 min
5. Synthetic whole embryo models and their applications- Prof. Jacob (Yaqub) Hanna
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31 min
6. Scale-up challenges in the production of nanomedicines from lab to industry- Prof. Dr. Oya Tagit
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14 min
7. Artificial intelligence in precision medicine- Dr. Michael P. Menden
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30 min
8. Translational medicine: the risk of failure in delay and how to reduce it- Prof. Martin Wehling
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8 min
9. Challenges and solutions of scaling up- Dr. Shaukat Ali
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15 min
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31 min
11. Management of generic drug development: challenges and opportunities- Mr. Sandeep Patil
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10 min
12. MassBank development and future- Dr. Emma L. Schymanski
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31 min
13. Elite controllers of HIV: from discovery to future therapies- Prof. Bruce Walker
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25 min
14. Translational research in amyotrophic lateral sclerosis (ALS)- Prof. Aaron D. Gitler
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10 min
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25 min
16. PANDAS: a potential link between group A streptococcal infections and neurological disorders- Prof. P. Patrick Cleary
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29 min
17. Rheumatic diseases and musculoskeletal pain- Prof. Anisur Rahman
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23 min
18. Towards developing a universal influenza vaccine- Prof. Peter Palese
- Clinical interviews
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21 min
19. Monkeypox: etiopathogenesis, prevention, and treatments- Dr. Dennis Hruby
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13 min
20. Kidney xenotransplantation- Dr. Douglas J. Anderson
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28 min
21. CAR-T and TCR-T cellular immunotherapies in oncology- Prof. Sebastian Kobold
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28 min
22. MAPS: the business of medical affairs- Dr. Danie du Plessis
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26 min
23. Hypertrophic cardiomyopathy: therapies and treatments- Prof. Srihari Naidu
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24 min
24. Combating the HIV epidemic- Prof. William Blattner
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17 min
25. Epigenetic pharmaceuticals used in the clinic- Dr. Thomas Paul
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21 min
26. Precision cancer medicine: development and future- Prof. Maurie Markman
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31 min
27. Pediatric cancer testing- Prof. Joshua Schiffman
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27 min
28. Opposition to vaccination: a transatlantic discussion- Prof. Jonathan Temte
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26 min
29. Elective caesarean sections from an evolutionary perspective- Prof. Wenda Trevathan
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19 min
30. Antiphospholipid syndrome and Lupus- Prof. Graham Hughes
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16 min
31. Prescribing medications to children - a GP’s view- Dr. Amanda Simmons
Topics Covered
- Alzheimer’s disease
- Amyloid
- In vivo disease model
- Dug development
- MEG3
- Necroptosis
- Neuronal cell death
- Pathogenesis
- Stem cell
- Tau pathology.
Biography
Bart De Strooper is professor in dementia research at the University College London, UK. He has been the founding director of the UK Dementia Research Institute (2016-2023) and is now a group leader in the same institute. He is also parttime Professor of molecular medicine at the KU Leuven and VIB, Belgium.
De Strooper’s scientific work focuses on the understanding of the fundamental mechanisms that underlie Alzheimer’s disease. His major findings are the role of ADAM10 and presenilin/gamma-secretase in the proteolysis of the amyloid precursor protein and Notch, and he has worked on microRNA, mitochondria, and more recently on the role of the different brain cell types in the pathogenesis of Alzheimer’s Disease. He developed a novel theory for Alzheimer’s Disease which he called the cellular phase, to explain the long prodromal phase of the disorder. He received his M.D. in 1985 and Ph.D. in 1991 from KU Leuven. He worked as postdoctoral researcher in the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, in the laboratory of Carlos Dotti.
In 2018, Bart De Strooper, together with John Hardy, Christian Haas, and Michel Goedert, was awarded the Brain Prize for their ground-breaking research on the genetic and molecular basis of Alzheimer disease. Other awards include the Potamkin Award of the American Academy of Neurology in 2002 (USA), the 2003 Alois Alzheimer Award of the Deutscher Gesellschaft für Gerontopsychiatrie und psychotherapie (Germany), the Joseph Maisin Prize in 2005 for fundamental biomedical sciences, (FWO Flanders, Belgium), the 2008 Metlife Foundation Award for medical research (USA) and the 2018 European Grand Prix for Research (France).
Links
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External Links
Talk Citation
De Strooper, B. (2024, June 9). How and why neurons die in Alzheimer's disease? [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/JTEQ3247.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Bart De Strooper has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Audio Interview
How and why neurons die in Alzheimer's disease?
Published on June 9, 2024
17 min
A selection of talks on Neuroscience
Transcript
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