Registration for a live webinar on 'Phasing Out Animal Testing: A New Era for Pharmaceutical Innovation' is now open.
See webinar details
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Epidemiology
-
37 min
-
40 min
2. Epidemiology of obesity- Prof. Jacob Seidell
- Etiology and Causes
-
59 min
3. Metabolic, adipose tissue and muscle predictors of obesity- Prof. Ian Macdonald
-
41 min
4. Neural control of food intake and energy balance- Prof. Hans-Rudolf Berthoud
-
64 min
-
47 min
6. Dietary determinants of obesity- Prof. Arne Astrup
-
42 min
7. Physical inactivity as a determinant of obesity- Prof. Wim Saris
-
42 min
8. Environmental causes of obesity: sociocultural, built environment and economic factors- Prof. Shiriki Kumanyika
-
29 min
9. The developmental origins of obesity- Prof. David Barker
- Consequences of Obesity
-
46 min
10. Obesity, dyslipoproteinemia and inflammation- Prof. Robert Eckel
-
23 min
11. Pathophysiology and management of obesity related hypertension- Prof. Arya Sharma
-
22 min
12. Disorders of overeating- Prof. Albert Stunkard
-
20 min
13. Obesity, weight loss and health-related quality of life- Prof. Aila Rissanen
- Dr. Jarmo Kaukua
- Treatment Options
-
44 min
14. Lifestyle modification for weight control- Prof. Thomas Wadden
-
34 min
15. Bariatric / obesity surgery- Prof. Henry Buchwald
-
48 min
16. Can obesity be prevented in the current obesogenic environment?- Prof. Boyd Swinburn
-
28 min
17. Pharmacotherapy for obesity: why it is needed- Prof. Joe Proietto
-
35 min
18. Pharmacotherapy for obesity: hunger suppressors- Prof. Joe Proietto
- Latest Developments in the Field
-
60 min
19. Body composition- Dr. Steven Heymsfield
-
56 min
20. Adipose tissue metabolism and obesity- Dr. Max Lafontan
-
25 min
21. Obesity, present and future therapies- Prof. Sir Stephen Bloom
-
42 min
22. Energy expenditure in the lean and obese- Prof. Dale Schoeller
-
33 min
23. Obesity and adiponectin- Prof. Philipp Scherer
-
44 min
24. Ectopic fat: causes, consequences and treatment- Prof. Steven Smith
-
47 min
25. Adipose-immune interactions in obesity- Dr. Vishwa Dixit
-
39 min
26. Health benefits of intentional weight loss- Prof. Xavier Pi-Sunyer
-
39 min
27. Childhood obesity: implications for current and future health- Prof. Peter T. Katzmarzyk
-
46 min
- Archived Lectures - These lectures may not cover the latest advances in the field
-
41 min
29. Gastrointestinal peptides and food intake regulation- Prof. Sir Stephen Bloom
-
48 min
30. Obesity and mortality: questions and controversy- Prof. David Allison
-
37 min
31. Obesity, diabetes and the cluster of the metabolic syndrome- Prof. Peter Wilson
-
44 min
-
46 min
33. Health economics of obesity: new insights- Dr. Anne Wolf
-
34 min
34. Bariatric surgery: techniques and mechanisms of action- Prof. Walter Pories
-
39 min
35. Childhood obesity: implications for future health- Prof. Peter T. Katzmarzyk
-
14 min
-
46 min
Printable Handouts
Navigable Slide Index
- Introduction
- Factors related to obesity and mortality
- BMI and probability of death
- The elevation in MR in the low BMI
- Effect of BMI on risk of death given vehicle collision
- Survival curves for base population and Mr. X
- YLL at various ages and BMI levels
- YLL after age 40 due to overweight and obesity
- Is something wrong with the universe?
- Weight loss increases life span in mice
- Impact of bariatric surgery on mortality rate
- Intentional and unintentional weight lose
- Is self-described "intentional" WL really intentional
- Model of intentional weight loss
- Example of the effects of unintentional weight loss
- Intentional WL as a latent variable problem
- Higher weight is associated with increased MR
- Iconic presentation of WL vs. MR
- Attributable deaths
- Annual deaths attributable to overweight problems
- Effect of age on BMI with lowest MR
- Excess deaths associated with weight
- Disparity between two studies
- Change in reference category
- A rough breakedown of the reasons for disparity
- Calle et al. do not find a reduction in RR over time
- How do we explain Peeters et al. results?
- How do we explain Fontaine et al. results?
- Opinion and evidence on these 4 points
- A non-Bayesian perspective
- A Bayesian perspective
- The importance of body composition
- Using BMI in mortality analyses
- Body composition and mortality
- Weight loss vs. fat loss
- Some key issues for further research
- Conclusion
Topics Covered
- The relationship between obesity and mortality rate is complex
- Differences in associations and causal effects may exist both within and across species
- Obesity is clearly associated with elevated mortality rate and this association is generally presumed to reflect causation
- The epidemiological evidence regarding the effect of being overweight (but not obese) is less clear and more controversial
- Epidemiological evidence on the effects of weight loss on mortality rate among obese persons is even less clear
- Evidence seems to suggest that weight loss induced by methods generally recommended by the biomedical community will prolong life among obese persons
- Data strongly suggest that losing body fat, as opposed to just body weight, is what conveys the presumed benefit of weight loss on longevity
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Allison, D. (2007, October 1). Obesity and mortality: questions and controversy [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 21, 2025, from https://doi.org/10.69645/PSLL9063.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. David Allison has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
