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Hello, my name is
Snejana Krassova.
I'm a medical doctor specializing
in immunohematology and
working in the
pharmaceutical industry
with over 20 years
of experience,
15 of them being in hemophilia.
I'm presenting today
Factor VIII levels
in non-severe hemophilia.
I believe it's a very
pertinent and acute topic
as we dealing over
the years with
severe hemophilia.
Let's discuss a little bit
more about non-severe
hemophilia.
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Hemophilia is a congenital
bleeding disorder characterized
by lack of factor VIII or
factor IX coagulation factors.
As we know overall,
for all hemophilias,
the incidence is about 7,500
live male births that
have been documented.
95% of the affected are males.
Females can be affected as well,
it's about 5%.
Female carriers obviously are
involved very much in this
disorder because it's
X-linked disorder and 30% of
cases are genetic mutations
that end out of blue,
there is no hereditary
pattern identified.
All races and socioeconomic
groups are equally affected.
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We have devised the
degrees of severity.
Severe hemophilia is a lack of
factor VIII or
factor IX below 1%.
That brings us to mild
and moderate hemophilia.
We over the years,
lumped them together, but
they're quite different.
We'll talk about that
later in the next slides,
but moderate hemophilia is
usually considered 1-5% and
mild hemophilia is about 5%
between 5% to below
50% slightly below 50,
because normal factor VIII and
factor IX levels are
considered 50-150%.
These are arbitrary decisions
in terms of the classification.
We've been using them for years
and today we discuss
a little bit more.
I mean, how is it levels
versus actual bleeding
patterns in these conditions?
And what factor levels we
should be striving for
in all of these situations in
terms of mild and
moderate hemophilia?
Knowledge and severity,
