• Design
• 34 min
  1. An introduction to randomization for clinical trials 1

  • Prof. William Rosenberger
• 20 min
  2. An introduction to randomization for clinical trials 2

  • Prof. William Rosenberger
• 42 min
  3. Randomisation, blinding and drug supply in interactive voice response trials

  • Mr. Damian McEntegart
• 42 min
  4. Randomization in clinical trials: time for fresh consideration?

  • Dr. Alex Sverdlov
• Analysis
• 32 min
  5. Design and conduct of non-inferiority trials

  • Prof. Valerie Durkalski-Mauldin
• 37 min
  6. Nonparametric covariate adjustment

  • Prof. Michael Akritas
• 34 min
  7. The impact of randomization on the evidence of a clinical trial

  • Prof. Nicole Heussen
• Theory
• 43 min
  8. Historical and ethical issues in trial design

  • Dr. J. Rosser Matthews
• 52 min
  9. Likelihood ratios and the strength of statistical evidence

  • Prof. Jeffrey Blume
• 36 min
  10. Biomarkers and surrogate endpoints in randomized clinical trials

  • Dr. Marc Buyse
• Randomization, Masking and Allocation Concealment
• 22 min
  11. Detection of and adjustment for selection bias in randomized controlled clinical trials

  • Prof. Lieven Nils Kennes
• 46 min
  12. Innovative and effective subject randomization methods

  • Prof. Wenle Zhao
• 12 min
  13. Selection bias in studies with unequal allocation

  • Dr. Olga M. Kuznetsova
• Archived Lectures *These may not cover the latest advances in the field
• 45 min
  14. Design and conduct of equivalence trials

  • Prof. Valerie Durkalski-Mauldin
• 19 min
  15. Dose-finding trials in oncology

  • Prof. Anastasia Ivanova
• 32 min
  16. Allocation concealment, prediction and selection bias

  • Prof. David Torgerson
• 41 min
  17. Pseudo cluster randomization

  • Dr. George Borm
• 26 min
  18. Introduction to flexible, adaptive trial design

  • Dr. Cyrus Mehta
• 30 min
  19. Randomization in clinical trials

  • Prof. William Rosenberger
• 35 min
  20. Novel methods for randomizing

  • Dr. William Grant
• 20 min
  21. Permutation tests

  • Dr. YanYan Zhou
• 59 min
  22. Handling multiplicity due to multiple primary or composite endpoints in clinical trials

  • Dr. Abdul Sankoh
• 32 min
  23. Multiple analyses in clinical trials

  • Prof. Lemuel Moye
• 26 min
  24. Handling of missing data in clinical trials

  • Dr. Linda Yau
• 35 min
  25. A note on the application of post-randomization adjustment

  • Dr. Xun Chen
• 24 min
  26. N-of-1 randomized clinical trials

  • Prof. Patrick Onghena

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Overview
3. The single case controlled observations history
4. A long history with influential applications (1)
5. A long history with influential applications (2)
6. A long history with a growing impact
7. N-of-1 RCT definition
8. The funnel approach to measurement (1)
9. The funnel approach to measurement (2)
10. The randomized experimental approach
11. Two types of designs
12. Phase design
13. Alternation design
14. Two types of replication
15. Simultaneous replication design
16. Sequential replication design
17. How to randomize and analyze?
18. Random assignment in phase designs
19. Graphic demonstration of random assignment
20. Phase design: numerical example (1)
21. Phase design: numerical example (2)
22. Random assignment in alternation designs (1)
23. Random assignment in alternation designs (2)
24. Alternation design: numerical example
25. Simultaneous replication design (1)
26. Simultaneous replication design (2)
27. Sequential replication design (1)
28. Sequential replication design (2)
29. Validity of N-of-1 RCTs
30. External validity of N-of-1 RCTs
31. Conclusion
32. References (1)
33. References (2)
34. References (3)
35. References (4)

Topics Covered

• History and impact of N-of-1 RCTs
• Distinguishing N-of-1 RCTs: case studies and time series research
• The funnel approach to measurement
• The randomized experimental approach
• Types of N-of-1 designs and replications
• How to randomize and analyze
• Validity of N-of- 1 RCTs

Links

Series:

• Design and Analysis of Randomized Clinical Trials

Categories:

• Methods
• Pharmaceutical Sciences

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. Patrick Onghena has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.