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1. Introduction
2. Overview
3. The single case controlled observations history
4. A long history with influential applications (1)
5. A long history with influential applications (2)
6. A long history with a growing impact
7. N-of-1 RCT definition
8. The funnel approach to measurement (1)
9. The funnel approach to measurement (2)
10. The randomized experimental approach
11. Two types of designs
12. Phase design
13. Alternation design
14. Two types of replication
15. Simultaneous replication design
16. Sequential replication design
17. How to randomize and analyze?
18. Random assignment in phase designs
19. Graphic demonstration of random assignment
20. Phase design: numerical example (1)
21. Phase design: numerical example (2)
22. Random assignment in alternation designs (1)
23. Random assignment in alternation designs (2)
24. Alternation design: numerical example
25. Simultaneous replication design (1)
26. Simultaneous replication design (2)
27. Sequential replication design (1)
28. Sequential replication design (2)
29. Validity of N-of-1 RCTs
30. External validity of N-of-1 RCTs
31. Conclusion
32. References (1)
33. References (2)
34. References (3)
35. References (4)

Topics Covered

• History and impact of N-of-1 RCTs
• Distinguishing N-of-1 RCTs: case studies and time series research
• The funnel approach to measurement
• The randomized experimental approach
• Types of N-of-1 designs and replications
• How to randomize and analyze
• Validity of N-of- 1 RCTs

Links

Series:

• Design and Analysis of Randomized Clinical Trials

Categories:

• Methods
• Pharmaceutical Sciences

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. Patrick Onghena has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.