• Design
• 34 min
  1. An introduction to randomization for clinical trials 1

  • Prof. William Rosenberger
• 20 min
  2. An introduction to randomization for clinical trials 2

  • Prof. William Rosenberger
• 42 min
  3. Randomisation, blinding and drug supply in interactive voice response trials

  • Mr. Damian McEntegart
• 42 min
  4. Randomization in clinical trials: time for fresh consideration?

  • Dr. Alex Sverdlov
• Analysis
• 32 min
  5. Design and conduct of non-inferiority trials

  • Prof. Valerie Durkalski-Mauldin
• 37 min
  6. Nonparametric covariate adjustment

  • Prof. Michael Akritas
• 34 min
  7. The impact of randomization on the evidence of a clinical trial

  • Prof. Nicole Heussen
• Theory
• 43 min
  8. Historical and ethical issues in trial design

  • Dr. J. Rosser Matthews
• 52 min
  9. Likelihood ratios and the strength of statistical evidence

  • Prof. Jeffrey Blume
• 36 min
  10. Biomarkers and surrogate endpoints in randomized clinical trials

  • Dr. Marc Buyse
• Randomization, Masking and Allocation Concealment
• 22 min
  11. Detection of and adjustment for selection bias in randomized controlled clinical trials

  • Prof. Lieven Nils Kennes
• 46 min
  12. Innovative and effective subject randomization methods

  • Prof. Wenle Zhao
• 12 min
  13. Selection bias in studies with unequal allocation

  • Dr. Olga M. Kuznetsova
• Archived Lectures *These may not cover the latest advances in the field
• 45 min
  14. Design and conduct of equivalence trials

  • Prof. Valerie Durkalski-Mauldin
• 19 min
  15. Dose-finding trials in oncology

  • Prof. Anastasia Ivanova
• 32 min
  16. Allocation concealment, prediction and selection bias

  • Prof. David Torgerson
• 41 min
  17. Pseudo cluster randomization

  • Dr. George Borm
• 26 min
  18. Introduction to flexible, adaptive trial design

  • Dr. Cyrus Mehta
• 30 min
  19. Randomization in clinical trials

  • Prof. William Rosenberger
• 35 min
  20. Novel methods for randomizing

  • Dr. William Grant
• 20 min
  21. Permutation tests

  • Dr. YanYan Zhou
• 59 min
  22. Handling multiplicity due to multiple primary or composite endpoints in clinical trials

  • Dr. Abdul Sankoh
• 32 min
  23. Multiple analyses in clinical trials

  • Prof. Lemuel Moye
• 26 min
  24. Handling of missing data in clinical trials

  • Dr. Linda Yau
• 35 min
  25. A note on the application of post-randomization adjustment

  • Dr. Xun Chen
• 24 min
  26. N-of-1 randomized clinical trials

  • Prof. Patrick Onghena

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Outline
3. Post-randomization adjustment
4. Why post-randomization adjustment?
5. Example (1)
6. Example (2)
7. Regression based method
8. A scheme demonstrating the two models (1)
9. Concerns on the conventional method (I)
10. A scheme demonstrating the two models (2)
11. Concerns on the conventional method (II)
12. Concerns on the conventional method (III)
13. Conventional method (III) - continue
14. Alternative methods (I)
15. Alternative methods (II)
16. Alternative methods (II) - continue
17. Alternative methods (III)
18. Alternative methods (III) - continue
19. Simulation
20. Simulation (cont.): conventional regression method
21. Simulation (cont.): simple stratification (1)
22. FGP/TG values distribution in 4 sub-groups (1)
23. Simulation (cont.): simple stratification (2)
24. Simulation (cont.): principle stratification (1)
25. FGP/TG values distribution in 4 sub-groups (2)
26. Simulation (cont.): principle stratification (2)
27. Conclusions
28. References

Topics Covered

• Adjustment for post-randomization variables: uses in practice to obtain additional information in randomized experiments
• Potential problems of the conventional regression based post-randomization adjustment method: reliability, precision and causality
• Available alternative methods that could provide either more powerful, less biased evaluation or more appropriate assessment for causality
• Examples of the application of the different post-randomization adjustment methods

Links

Series:

• Design and Analysis of Randomized Clinical Trials

Categories:

• Methods
• Pharmaceutical Sciences

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Dr. Xun Chen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.