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Role of the lymphatic system in drug absorption

Published on May 31, 2023   33 min

A selection of talks on Pharmaceutical Sciences

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0:00
Hello, my name is Kishor Wasan. I'm currently a Distinguished University Scholar and Adjunct Professor in the Department of Biological Sciences in the Faculty of Medicine at the University of British Columbia, as well as the co-director and co-founder of our Neglected Global Diseases Initiative. I was a professor at UBC and then was a Dean of a pharmacy school on the prairies, retired from there and have now come back to my former university. Today I'd like to talk to you about a very neat and niche area of how we can enhance the oral absorption of drugs and its bioavailability.
0:34
The outline for my presentation today is the following, what is lymphatic transport? What are the drug properties required for lymphatic transport? What did become the characteristics of lymphatic transport? Then I wanted to give you some key actual examples where drugs that are your package into lipid packages that can enhance lymphatic transport are done or drugs themselves or nutrients that had the characteristics that make them ideal for lymphatic transport.
1:04
Over the years, a number of different research groups have worked together in developing key principles and properties that would make a drug candidate, a good candidate for lymphatic transport. Kind of like how we have the Lipinski rule of five, we've come down with four fundamental critical properties that seemed to be required in order for a drug to be able to absorb using the mechanisms of lymphatic transport. The first one is the cLog P being greater than five, that is the optimal water coefficient. The idea here is that a drug that's very lipophilic, water-loving in its properties with greater of 5:1 ratio is something that would be viable for lymphatic transport. The second is triglyceride solubility. That a drug has a high solubility and triglycerides usually greater than 50 milligrams per mil, and it's usually a function of medium-chain triglycerides and long-chain triglycerides. A third factor is the ability of the drug to partition into chylomicrons. Chylomicrons are triglyceride-rich lipoproteins, and usually anywhere between 40% distribution into chylomicrons makes this an ideal candidate for lymphatic transport. Finally, most drugs usually have to be small molecules and have a molecular weight less than 500.

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Role of the lymphatic system in drug absorption

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