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- Research interviews
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25 min
1. Synthetic whole embryo models and their applications- Prof. Jacob (Yaqub) Hanna
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31 min
2. Scale-up challenges in the production of nanomedicines from lab to industry- Prof. Dr. Oya Tagit
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14 min
3. Artificial intelligence in precision medicine- Dr. Michael P. Menden
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30 min
4. Translational medicine: the risk of failure in delay and how to reduce it- Prof. Martin Wehling
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8 min
5. Challenges and solutions of scaling up- Dr. Shaukat Ali
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15 min
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31 min
7. Management of generic drug development: challenges and opportunities- Mr. Sandeep Patil
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10 min
8. MassBank development and future- Dr. Emma L. Schymanski
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31 min
9. Elite controllers of HIV: from discovery to future therapies- Prof. Bruce Walker
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25 min
10. Translational research in amyotrophic lateral sclerosis (ALS)- Prof. Aaron D. Gitler
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10 min
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25 min
12. PANDAS: a potential link between group A streptococcal infections and neurological disorders- Prof. P. Patrick Cleary
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29 min
13. Rheumatic diseases and musculoskeletal pain- Prof. Anisur Rahman
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23 min
14. Towards developing a universal influenza vaccine- Prof. Peter Palese
- Clinical interviews
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21 min
15. Monkeypox: etiopathogenesis, prevention, and treatments- Dr. Dennis Hruby
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13 min
16. Kidney xenotransplantation- Dr. Douglas J. Anderson
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28 min
17. CAR-T and TCR-T cellular immunotherapies in oncology- Prof. Sebastian Kobold
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28 min
18. MAPS: the business of medical affairs- Dr. Danie du Plessis
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26 min
19. Hypertrophic cardiomyopathy: therapies and treatments- Prof. Srihari Naidu
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24 min
20. Combating the HIV epidemic- Prof. William Blattner
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17 min
21. Epigenetic pharmaceuticals used in the clinic- Dr. Thomas Paul
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21 min
22. Precision cancer medicine: development and future- Prof. Maurie Markman
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31 min
23. Pediatric cancer testing- Prof. Joshua Schiffman
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27 min
24. Opposition to vaccination: a transatlantic discussion- Prof. Jonathan Temte
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26 min
25. Elective caesarean sections from an evolutionary perspective- Prof. Wenda Trevathan
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19 min
26. Antiphospholipid syndrome and Lupus- Prof. Graham Hughes
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16 min
27. Prescribing medications to children - a GP’s view- Dr. Amanda Simmons
Topics Covered
- Differentiation
- Early development
- Ex utero growth
- Gastrulation
- Mouse embryo
- Organogenesis
- Research
- Stem cells
- Transplantation
Biography
Born in Rama, an Arab Palestinian village in the Galilee region of Israel, Prof. Jacob (Yaqub) Hanna earned his BSc in medical science (2001), PhD in immunology (2007), and MD in clinical medicine summa cum laude (2007) from the Hebrew University of Jerusalem. He conducted postdoctoral research at the Whitehead Institute for Biomedical Research at MIT. He joined the department of Molecular Genetics at the Weizmann Institute in 2011.
Prof. Hanna is pioneering techniques in induced naïve pluripotency from adult cell and synthetic whole embryo models made solely from stem cells ex utero. Prof. Hanna was the lead researcher in a study that showed how further-modified iPS cells could be used to treat sickle-cell anemia in mice, the first proof of concept of the therapeutic application of iPS cells. He was the first to expand prolonged periods of advanced and normal mammalian embryo development from pre-gastrulation until late organogenesis in an “artificial uterus” environment outside the maternal womb. The latter platform enabled him to demonstrate the ability to be the first to generate advanced stage whole synthetic embryos made entirely from naïve pluripotent stem cells in the petri dish, that can complete gastrulation and demonstrate organ formation within adequate extra-embryonic compartments. In addition to demonstrating the power of cell reprogramming and ex utero synthetic advanced embryogenesis, his work offers the promise of powerful new research models for degenerative diseases, infertility, and modelling human early development.
During his postdoctoral work, Prof. Hanna received a prestigious Novartis Fellowship from the Helen Hay Whitney Foundation. In 2010, he was awarded the Sir Charles Clore Prize for Outstanding Appointment in the Weizmann Institute. He received an EMBO young investigator award (2012), a Rappaport Prize in biomedical research (2013), a Krill Prize by the Wolf Foundation (2013), and the Helen and Martin Kimmel Award for Innovative Investigation (2014). In 2014, he was featured among “40 under 40” innovative scientists by the prestigious journal Cell and was elected as a member of EMBO in 2018. In 2021, he ranked at the top of the list of 50 leading world thinkers by Prospect magazine.
Links
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External Links
Talk Citation
Hanna, J.(. (2022, December 15). Synthetic whole embryo models and their applications [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/5152/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Jacob (Yaqub) Hanna has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Audio Interview
Synthetic whole embryo models and their applications
Published on December 15, 2022
25 min
A selection of talks on Reproduction & Development
Transcript
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