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0:00
Hello, my name is
Peter Lipke from
the Department of Biology at
Brooklyn College of the City
University of New York.
Today I'm going to
talk about glycans and
glycoproteins in the cell walls
of yeast and other fungi.
0:16
Fungal cell walls
are not well known,
but they are the
cellular equivalent of
the extracellular
matrix in animal cells.
They have many of
the same functions,
including protection
of the cell surface
and interaction with
the environment.
We're going to talk
about the structure and
biosynthesis of the
components of the cell walls
and about relatively
recent discoveries
about how the cell walls
are assembled and modified.
On this slide, you see some
electron micrographs of
yeast cell walls, mostly with
the extracellular
environment at the top.
The visible structures
are the walls.
The membranes are not visible
in these micrographs,
but you can see the
cytoplasm interior
to the membrane
towards the bottom.
On the left to the
slide, you see
a cartoon of the arrangement
of the components of
the cell wall and we'll
use this cartoon to
orient ourselves as we
go through the lecture.
If you look at the
bottom of the slide,
there are the reference numbers
for this particular slide.
The last two slides are
a bibliography with
numbered references,
so you can access the
relevant literature.
1:21
This lecture will
have eight sections.
First, we will talk about
graphic conventions for
how we depict the glycans.
Next, we will talk about
the overall architecture
of yeast cell walls.
The third section will
include the structure and
biosynthesis of individual
components of the wall.
Then, we will have a section
about the assembly
and cross-linking
of all of these components
into a macromolecular complex.
Fifth, we will talk about
how the wall is modified to
accommodate both
environmental needs
and the needs of cellular
differentiation.
Sixth is a brief
discussion about how
general the model is across
the evolution of fungi.
Seventh is a one-slide
summary of interactions
between wall components and
the mammalian immune system,
a subject that would be
a separate series of
lectures based on
thousands of papers.
Finally, there is a brief
recap and bibliography.
