• Defining Retroviruses
• 38 min
  1. An introduction to retroviruses: replication strategy and genetics

  • Dr. Jonathan Stoye
• The First Human Retroviruses
• 65 min
  2. The discovery of human retroviruses and how they cause disease

  • Prof. Robert Gallo
• HIV Transmission, Epidemiology and Public Health/Prevention Issues
• 42 min
  3. HIV/AIDS epidemiology, transmission, and risk factors

  • Prof. William Blattner
• 55 min
  4. HIV prevention and public health issues: a global perspective

  • Prof. Sten H. Vermund
• How HIV causes AIDS
• 35 min
  5. How HIV causes disease 1: identification and characterization of HIV

  • Prof. Bruce Walker
• 43 min
  6. How HIV causes disease 2: immune responses to HIV infection

  • Prof. Bruce Walker
• HIV Therapy - Now and the Future
• 34 min
  7. HIV therapy: taking advantage of progress

  • Prof. Paul Volberding
• 39 min
  8. HIV cure: harnessing innate and adaptive strategies

  • Prof. Luis Montaner
• Archived Lectures *These may not cover the latest advances in the field
• 36 min
  9. The first human retroviruses: the human T lymphotropic viruses (HTLVs)

  • Prof. William Hall
• 59 min
  10. HIV preventive vaccines

  • Prof. Andrew McMichael
• 31 min
  11. HIV/AIDS in the developing world: what can we do?

  • Dr. Joseph O'Neill
• 54 min
  12. Human T-cell leukemia virus type 1 (HTLV-1) and adult T-cell leukemia: insights into cellular transformation

  • Prof. Kuan-Teh Jeang
• 41 min
  13. Antiretroviral therapy 2007, new concepts and lessons learned

  • Prof. Robert Redfield
• 29 min
  14. What to do in therapy in the face of HIV drug resistance?

  • Prof. Mark Wainberg
• 42 min
  15. Viral reservoirs, latency and mechanisms of HIV persistence

  • Prof. Robert Siliciano
• 28 min
  16. HIV preintegration complexes

  • Prof. Lee Ratner
• 30 min
  17. The discovery of ATL field expansion in 40 yrs

  • Prof. Junji Yodoi
• 45 min
  18. Bovine leukemia virus

  • Prof. Arsene Burny
  • Dr. Lucas Willems
• 11 min
  19. HIV: peculiarities of its genome

  • Dr. George Pavlakis

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. HIV
3. Cell cycle progression and retrovirus replication
4. Resting T cells and HIV
5. Link between uncoating and PIC nuclear import
6. Preintegration complex (PIC)
7. Intracellular transport of PICs
8. The HIV-1 PIC has multiple components with NLS
9. HIV-1 Vpr vs. HIV-2 Vpx
10. HIV-1 Vpr interaction factors
11. Cellular proteins that influence PIC import or action
12. HIV-2
13. HIV-2: model system for PIC nuclear import
14. Vpx cellular localization
15. Cellular localization of LacZ-fusions (1)
16. Cellular localization of LacZ-fusions (2)
17. Alignment of HIV-2/SIV Vpx amino acids 61-79
18. Identifying residues critical for PIC nuclear import
19. Nuclear localization signal of HIV-2 Vpx
20. Vpx interaction with Hsp40
21. Heat shock proteins
22. Heat shock proteins and viruses
23. Vpx interacts with Hsp40/DnaJB6 (1)
24. Vpx interacts with Hsp40/DnaJB6 (2)
25. DnaJB6 over expression and Vpx packaging
26. Hsp40/DnaJB6 enhances Vpx nuclear localization
27. DnaJB6 down regulation and PIC nuclear import
28. Novel mechanism for Vpx-mediated PIC import
29. Nuclear import inhibitors

Topics Covered

• Role of cell cycle progression in retrovirus replication
• Resting T-cells and HIV
• Uncoating and PIC nuclear import
• Preintegration complex (PIC)
• Intracellular transport of PIC
• HIV-1 Vpr vs. HIV-2 Vpx
• HIV-1 Vpr interaction factors
• HIV-2: model system for PIC nuclear import
• Vpx cellular localization
• Ability of Vpx-NLS mutant viruses to infect arrested and dividing U937 cells
• Nuclear localization signal of HIV-2 Vpx
• Vpx interaction with HSP 40
• Heat shock proteins and viruses
• Over-expression of DNAJB6 causes reduction of Vpx packaging in VLP
• Down regulation of DNAJB6 reduces nuclear import of HIV-2 PIC
• Novel mechanism of Vpx-mediated PIC import

Links

Series:

• Retroviruses

Categories:

• Biochemistry
• Cell Biology
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on December 10, 2018

Financial Disclosures

• Prof. Lee Ratner has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.