• Defining Retroviruses
• 38 min
  1. An introduction to retroviruses: replication strategy and genetics

  • Dr. Jonathan Stoye
• 45 min
  2. Bovine leukemia virus

  • Prof. Arsene Burny
  • Dr. Lucas Willems
• The First Human Retroviruses
• 65 min
  3. The discovery of human retroviruses and how they cause disease

  • Prof. Robert Gallo
• HIV - Peculiarities of its Genome
• 11 min
  4. HIV: peculiarities of its genome

  • Dr. George Pavlakis
• HIV Transmission, Epidemiology and Public Health/Prevention Issues
• 42 min
  5. HIV/AIDS epidemiology, transmission, and risk factors

  • Prof. William Blattner
• 55 min
  6. HIV prevention and public health issues: a global perspective

  • Prof. Sten H. Vermund
• How HIV causes AIDS
• 35 min
  7. How HIV causes disease 1: identification and characterization of HIV

  • Prof. Bruce Walker
• 43 min
  8. How HIV causes disease 2: immune responses to HIV infection

  • Prof. Bruce Walker
• HIV Therapy - Now and the Future
• 34 min
  9. HIV therapy: taking advantage of progress

  • Prof. Paul Volberding
• 39 min
  10. HIV cure: harnessing innate and adaptive strategies

  • Prof. Luis Montaner
• Archived Lectures *These may not cover the latest advances in the field
• 36 min
  11. The first human retroviruses: the human T lymphotropic viruses (HTLVs)

  • Prof. William Hall
• 59 min
  12. HIV preventive vaccines

  • Prof. Andrew McMichael
• 31 min
  13. HIV/AIDS in the developing world: what can we do?

  • Dr. Joseph O'Neill
• 54 min
  14. Human T-cell leukemia virus type 1 (HTLV-1) and adult T-cell leukemia: insights into cellular transformation

  • Prof. Kuan-Teh Jeang
• 41 min
  15. Antiretroviral therapy 2007, new concepts and lessons learned

  • Prof. Robert Redfield
• 29 min
  16. What to do in therapy in the face of HIV drug resistance?

  • Prof. Mark Wainberg
• 42 min
  17. Viral reservoirs, latency and mechanisms of HIV persistence

  • Prof. Robert Siliciano
• 28 min
  18. HIV preintegration complexes

  • Prof. Lee Ratner
• 30 min
  19. The discovery of ATL field expansion in 40 yrs

  • Prof. Junji Yodoi

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Introduction of Retorovirus
3. Disease derived from Retorovirus
4. Discovery of ATL disease entity
5. HTLV-1 discovery and world-wide distribution
6. Gallo meeting, Kyoto (12.01.03)
7. Cloning of IL-2 receptor alpha chain
8. Discovery of ATL-derived factor (ADF)
9. ADF is the human thioredoxin (TRX)
10. Regulation of thioredoxin gene expression
11. TRX transgenic and knock-out mice
12. Survival and influenza resistance of TRX TG mice
13. The thioredoxin system
14. Thioredoxin superfamily
15. IgE binding factor, GIF/MIF and TRX
16. ADF peptide sequence A and B
17. Dualistic function of MIF/GIF
18. Inhibition of MIF expression by exogenous rhTRX
19. Reciprocal regulation of TRX and GIF/MIF
20. TRX1/ADF as an endogenous inhibitor of MIF/GIF
21. Modulation of inflammation and cell death by TRX
22. Modified TRX1 rapidly enters into cells (1)
23. Modified TRX1 rapidly enters into cells (2)
24. Raft fractionation of TRX-C35S-expressing cells
25. rTRX-C35S interanalization is competed by wtTRX
26. Lipid raft-mediated TRX transfer into cells
27. rTRX suppresses bleomycin-induced lung injury
28. Therapeutic effect of rTRX against lung disease
29. Resistance against allergic inflammation/COPD
30. Attenuation of Indomethacin-induced gastric ulcer
31. Influenza virus infection resistance
32. Possible aplication of rTRX in respiratory infections
33. Thioredoxin binding proteins
34. TBP-2 - a TRX binding protein
35. TBP-2: tumor suppressor for HTLV-I leukemia
36. TBP-2 knock-out and transgenic mice
37. Thiol-dependent redox regulatory network update
38. Clinical trials involving rTRX
39. Redox research, International Redox Network

Topics Covered

• Life cycle of retroviruses
• Diseases derived from retroviruses
• Adult T-cell leukemia and HTLV-1 retrovirus
• ADF/TRX upregulation in HTLV-I T-cell and EBV B-cell transformation
• Regulation of thioredoxin gene expression
• TRX TG and KO mice
• The thioredoxin system
• MIF/GIF
• Inflammatory response
• TBP2: tumor suppressor for HTLV-I leukemia
• Clinical trials for inflammatory diseases

Links

Series:

• Retroviruses

Categories:

• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Junji Yodoi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.