Oral drug delivery

Published on April 28, 2022   34 min

A selection of talks on Clinical Practice

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Hi. My name is Vineet Kumar Rai. I am an associate professor in Pharmacy Discipline and Head of the Department of Pharmaceutics at ISF College of Pharmacy, Moga, Punjab. The subject of this lecture is oral drug delivery. The focus is on the oral route for both local and systemic uses.
This slide shows an outline of the lecture. After a brief introduction, the significant advantages, disadvantages and challenges associated with the oral route of administration will be discussed. It further includes anatomy of the gastrointestinal tract, its components, functions, different barriers against oral drug delivery, factors to be considered for oral administration and most suitable dosage forms.
The introduction slide shows the paramount importance of drug delivery. As far as the current market share of the oral drug delivery system is concerned, it is about 90%. At the same time, it covers nearly 84% of the best-selling pharmaceutical products with a value of 35 billion US dollars. This market is growing at a phenomenal rate that is more than 10% annually. Hence, these factors prove the oral route is the most preferred route for drug administration. Why is it so?
It is because the oral route is well-known for its painless administration. It allows easy administration by the patient themselves, since taking anything orally is convenient. It offers great patient compliance. Furthermore, it is a cost-effective method compared with the other routes and it doesn't require any specific or sterile condition during dosage form development and administration. We all practice self-administration from our mouth and it doesn't require any expert for the same purpose. Additionally, the lumen of the gastrointestinal tract offers an enormous surface area for drug absorption through the entire length of the gastrointestinal tract. The formulation scientists always have flexibility in designing different dosage forms for the administration of the drugs by oral routes. Therefore, every dosage form has been developed to date, ranging from liquid dosage forms to solid dosage forms. Moreover, it offers great ease in scale-up and large-scale manufacturing.