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1. Introduction
2. Content
3. Protease and inhibitor activities
4. Known proteases in the human genome
5. Human thiol-dependent cathepsins
6. The term "cathepsin"
7. Cathepsin K structure, expression and activity
8. Cathepsin K structure
9. Cathepsin K domain structure
10. Cathepsin K tissue distribution
11. Cathepsin K substrate specificity
12. Inhibition of cathepsin K
13. Cleavage of type I collagen by cathepsin K
14. What makes cathepsin K a unique collagenase?
15. Cathepsin K hydrolyses triple helical collagen
16. Activity of cathepsin K
17. Effect of chondroitin sulfate (CS)
18. Cathepsin K/CS complex identification
19. Cathepsin K/chondroitin complex formation
20. Collagenolytic activity and complex formation
21. Evidence that cathepsin K complexes exist in vivo
22. Pycnodysostosis
23. Pycno mutant Y212C has no collagenase activity
24. Pycno mutant Y212C does not form complexes
25. Collagens degradation by MMPs and cathepsins
26. Cathepsin K in osteoporosis
27. The human skeleton
28. Osteoclast activity
29. Cathepsin K and its expression in osteoclasts
30. Osteoporosis
31. Bone resorption assay (pit assay)
32. Effect of inhibitors of cathepsins K and L
33. Ratio of urine NTx/creatinine
34. Cathepsin K and osteoporosis (summary)
35. Cathepsin K in arthritis
36. Arthritis
37. Rheumatoid arthritis (RA)
38. Cell types involved in cartilage and bone erosion
39. Major bone and cartilage matrix proteins
40. Cathepsin K expression in the inflamed synovium
41. Expression of cathepsin K in the RA synovium
42. Cartilage erosion by CATK+ cells
43. Synovial cathepsin K expression and HFCQ
44. Scanning EM of MMP/cathepsin-digested cartilage
45. Inflammatory reaction involvement of cathepsin K
46. MHC class II antigen presentation
47. Expression of cathepsins K and S
48. Cathepsin K deficiency and CIA
49. Collagen-induced arthritis and cathepsins
50. Type II CIA (experimental model)
51. Ankle thickness of CIA
52. Diminished susceptibility to CIA
53. Bone erosion and cartilage damage
54. Cartilage degradation
55. Bone erosion
56. Potential cathepsin inhibitor therapy in RA
57. Conclusions

Topics Covered

• Cysteine proteases
• Cathepsin family
• Expression of cathepsins and their activity
• Collagen degradation
• Pycnodysostosis
• Cathepsin K in osteoporosis
• Cathepsin K in arthritis
• Mouse model of arthritis

Links

Series:

• Protein Epidemiology

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Dieter Bromme has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.