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Printable Handouts
Navigable Slide Index
- Introduction
- Transcription factors (TFs)
- Ligands of nuclear receptors
- Receptor-DNA binding and hormones
- Protein recruitment and hormones
- Classes of nuclear receptors
- Ligand structures: type I nuclear receptors
- Type I receptor antagonists
- Ligand structures: type II nuclear receptors
- The nuclear receptor superfamily
- Steroid receptors share 3 regions of homology
- Receptor isoforms regulate hormone response
- Isoforms of the human progesterone receptor
- Isoforms of the human glucocorticoid receptor
- DNA-binding domain homology
- Homology domains contain two zinc fingers
- Receptors' P-boxes and half-site binding sites
- Receptors binding a palindromic half site
- Receptors binding a direct repeat half site
- The hormone binding domain (1)
- The hormone binding domain (2)
- Role of helix 12 in the estrogen receptor alpha
- Steroid receptor action
- Where are unliganded steroid receptors?
- Role of receptor-heat shock proteins complex
- Protein recruitment and chromatin modification
- Coregulators of the nuclear receptor
- Identification of interacting proteins
- SRC/p160 coactivator family
- Nuclear receptor interaction motifs
- SRC/p160 coactivator family - the NR box
- Histone acetylation and chromatin structure
- Coactivators: proteins with diverse activities
- Nuclear Receptor Signaling Atlas (NURSA)
- Chromatin immunoprecipitation assay (1)
- Chromatin immunoprecipitation assay (2)
- Chromatin immunoprecipitation assay (3)
- Chromatin immunoprecipitation assay (4)
- Location of hormone response elements
- Type II nuclear receptors: mechanisms of action
- The thyroid hormone receptor
- The coregulator exchange
- Corepressors and type I nuclear receptors
- Independent transcriptional activation by NRs
- Repression of IL-8 expression
- Transrepression by activated nuclear receptors
- NRs regulate transcription by kinase activation
- Summary: steroid receptor action
Topics Covered
- Introduction to transcription factors
- Nuclear receptors as ligand-dependent transcription factors
- Classes of nuclear receptor
- Nuclear receptor ligands: agonists and antagonists
- Nuclear receptor phylogeny
- Nuclear receptor isoforms
- The nuclear receptor DNA-binding domain
- Hormone response elements
- The nuclear receptor ligand-binding domain
- Nuclear receptor mechanism
- Subcellular localization of nuclear receptors
- The effect of ligand binding
- Nuclear receptor coregulators
- Initial discoveries of coregulators
- The SRC/p160 coregulator family
- Nuclear receptor-coregulator interaction motifs
- Histone acetylation and chromatin structure
- The Nuclear Receptor Signaling Atlas (NURSA)
- Chromatin immunoprecipitation as a tool in nuclear receptor mechanism
- Functional differences between type I and type II nuclear receptors
- The coregulator exchange
- DNA-binding independent functions
- Transrepression
- The role of kinases
Talk Citation
Weigel, N. and McKenna, N. (2007, December 1). Nuclear receptors: transcriptional functions [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 4, 2024, from https://doi.org/10.69645/PGPK8119.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Nancy Weigel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Dr. Neil McKenna has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.