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- Clinical Introduction
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1. Frontotemporal dementia
- Prof. Bruce Miller
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2. Parkinson disease
- Prof. Stanley Fahn
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3. Atypical parkinsonian syndromes
- Dr. David Burn
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4. Huntington's disease
- Prof. Roger Barker
- Neuroimaging
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5. Molecular brain imaging (PET) in diseases with dementia
- Prof. Karl Herholz
- Pathology, Genetic and Molecular Aspects (1)
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6. A molecular understanding of Alzheimer's disease
- Prof. John Hardy
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7. Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
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9. Ubiquitination and Alzheimer related disorders
- Prof. John Mayer
- Pathology, Genetic and Molecular Aspects (2)
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10. The molecular biology of Huntington's disease
- Prof. David C. Rubinsztein
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11. Metals, oxidative stress and neurodegeneration
- Prof. Ashley Bush
- Latest Developments in the Field
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12. Animal models of tauopathy
- Prof. David Westaway
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13. Parkinson's disease and transplants
- Prof. Roger Barker
- Archived Lectures *These may not cover the latest advances in the field
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14. Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
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15. Motor neurone disease: molecular basis
- Prof. Kevin Talbot
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16. Alzheimer's disease (AD)
- Prof. John Hodges
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17. Frontotemporal dementia syndromes
- Prof. John Hodges
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18. Motor neurone disease: clinical aspects
- Prof. Kevin Talbot
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19. Neuro-imaging in dementia: using MRI in routine work-up
- Prof. Philip Scheltens
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20. Prion diseases
- Prof. Pierluigi Gambetti
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21. Mitochondrial disorders and neurodegeneration
- Prof. Anthony Schapira
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23. Mutations in parkinsonian syndromes
- Dr. Andrew Singleton
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25. Frontotemporal dementia
- Prof. Bruce Miller
Printable Handouts
Navigable Slide Index
- Introduction
- Overview (1)
- Neuropathology of neurodegeneration
- Assessing atrophy: determination of regional volumes
- Map of severity of atrophy
- Assessment of cellular changes
- Neuropathology of Ageing
- Age-associated accumulation of AD-type pathology
- Overview (2)
- AD: macroscopic pathology
- Regional atrophy in AD
- AD: Microscopic features
- A-beta (Aβ) plaques
- Neurofibrillary tangles (NFTs)
- Spread of Neurofibrillary tangles
- Evaluation of NFTs (Braak stage)
- Evaluation of neuritic plaques
- National Institute of Aging-Alzheimer’s Association Criteria for AD
- Neuron loss in AD
- Cholinergic neuron loss in AD
- Overview (3)
- Frontotemporal lobar degeneration
- Macroscopic findings
- Regional atrophy in FTLD
- FTLD: disease staging
- FTLD-tau: distribution by stage
- Microscopic pathology in FTLD – TDP-43
- Microscopic pathology in FTLD – tau
- FTLD – pathological classification
- Clinicopathological correlations
- Overview (4)
- Motor Neuron Disease
- ALS: microscopic pathology
- ALS: disease spread and staging
- Overlap: ALS and FTLD-TDP
- TDP staging – ALS and FTLD
- Overview (5)
- Lewy body diseases
- Regional atrophy in DLB
- LBD: neuropathological diagnosis
- DLB: other pathology
- Spread of Lewy bodies - Braak Staging
- Acknowledgments
- References
Topics Covered
- Pathologies seen in neurodegenerative disorders
- Alzheimer’s disease
- Frontotemporal dementia
- Amyotrophic lateral sclerosis and Lewy body diseases
- The macroscopic and microscopic features
- The nature and topography of protein deposits
- The pattern and extent of atrophy in neurodegenerative disorders
Talk Citation
Kril, J. (2021, June 29). Neuropathology of neurodegenerative disorders [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/RAWJ5806.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Jillian Kril has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Neuroscience
Transcript
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0:00
Hello, I'm Jillian Kril,
I'm a professor of neuropathology at the University of Sydney, and
this presentation is on the neuropathology of neurodegenerative disorders.
I will describe the major pathological features of common groups of neurodegenerative diseases.
0:19
I will focus on the four main groups of
disorders that are commonly encountered in clinical practice.
These are Alzheimer's disease (AD), frontotemporal dementias (FTD),
motor neurone disease (MND/ALS), and Lewy Body diseases (LBD).
However, as these terms are often used to describe
both the clinical and the pathological entity,
I will endeavor to use 'Alzheimer's disease neuropathological change'
instead of 'Alzheimer's disease', and 'frontotemporal lobar degeneration'
instead of 'frontotemporal dementia'.
Unfortunately, there aren't different terms used for
the pathology and clinical presentations of ALS or Lewy body diseases.
1:01
In discussing each of these neuropathological disorders,
I will focus on the macroscopic features of the disease, the extent, severity,
and anatomical distribution of atrophy in particular.
This is because atrophy can be paralleled in neuroimaging, and
therefore the information that we glean from
neuropathological studies can be used to inform clinical diagnoses.
I will also look at the microscopic features,
in particular the proteinopathies that differentiate
these neurodegenerative disorders, and their cellular and anatomical distribution.
I will also examine the neuropathological diagnostic criteria for each disorder.