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1. Introduction
2. Mechanisms to diabetes
3. The insulin response
4. Growth factor receptor tyrosine kinases
5. Insulin and its receptor
6. Insulin receptor
7. Insulin receptor transmembrane signaling
8. Insulin and IGF1 receptors exist as hybrids
9. Growth factor receptor tyrosine kinases
10. The substrate hypothesis of insulin action
11. The family of Irs-proteins
12. Insulin signaling cascade
13. Insulin stimulates GLU4 translocation
14. The insulin signaling cascade
15. The insulin signaling cascade inhibition
16. IRS-proteins mediated insulin action
17. IRS2 integrates central & peripheral homeostasis
18. IRS2 regulates hepatic glucose homeostasis
19. IRS2 signaling promotes glucose homeostasis
20. IRS signaling regulates the expression of Pdx-1
21. Integrated view of IRS signaling system

Topics Covered

• Mechanisms to diabetes
• The insulin response
• Growth factor receptor tyrosine kinases
• The insulin receptor
• The substrate hypothesis of insulin action
• The family of Irs-proteins
• The insulin signaling cascade
• Role of the Irs2 signaling system

Links

Series:

• Signal Transduction via Protein Tyrosine Kinase Receptors

Categories:

• Biochemistry
• Cell Biology
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Morris White has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.